Hadeel SM Reda*, Sanaa A Elzogby* And Marwa MS Abbass**,

ABSTRACT
Background: Osteoporosis Has A Direct Effect On Oral And Dental Health. Glucocorticoids Are The Most Frequent Cause Of Secondary Osteoporosis. The Potential Healing Effect Of Mesenchymal Stem Cell (MSCs) Was Not Completely Examined On Repairing Glucocorticoid Induced Osteoporosis (GI). The Present Study Was Carried Out To Clarify The Beneficialeffect Of MSCs In Treating GI-osteoporotic Bone. Methods: Twelve Adult Female Albino Rats Were Enrolled In This Study. All Rats Were Intraperitoneally Injected (IP) Once Daily With Dexamethasone For 60 Days In Order To Induce Osteoporosis. Dual Emission X-ray Absorptiometry (DEXA) Scanning After 30 Days Was Done To Ensure Occurrence Of Osteoporosis. The Rats Were Injected Weekly Below The Right Firstmandibular Molar Area With MSCs (MSCs Group). The Left Side Jaws (osteoporosis Group) Received Only 1 Ml Of Saline Injection Every Week In The Same Location. To Facilitate Comparison, Additional 6 Rats Were Used As A Control Group. The Control Rats Received IP Saline For 60 Days And Locally Injected In Molar Area At Both Sides 2 Times.

Results: The Highest Mean Bone Area % Was Recorded In MSCs Treated Group (83.140?1.108), While The Least Mean Bone Area % Was Recorded In The Osteoporotic Group (49.632?5.402). High Significantdifference In Bone Area % Was Recorded Between MSCs Group Versus The Osteoporotic Group (P<0.01) While An Insignificat Difference Was Revealed Between MSCs Group And The Control Group (P>0.05). Conclusion: In The Fieldof Bone Regeneration, MSCs Overcome The Limitations And Side Effects Associated With Other Medical Drugs Used To Control Osteoporosis.