Mohamed Ghaly, Amina El Hosary, Hatem Amin And Hanan Abdul Khaliq,

ABSTRACT
Aims: This Work Aimed To Evaluate The Effect Of Chlorhexidine Versus Fluoridevarnishes On Salivary Biomarkers Including Salivary PH And Streptococcus Mutants Counts Among Leukemic Children. Settings And Design: The Study Was Conducted As A Clinical Trial. The Clinical Part Was Carried Out At Pediatric Dentistry Department, Faculty Of Dentistry, Tanta University And The Laboratory Work Was Carried Out At Medical Microbiology And Immunology Department, Faculty Of Medicine, Tanta University. Subjects And Methods: 60 Leukemic Children In The Stabilization Phase Ranging In Age From 4-17 Years Were Included In The Study. The Selected Children Were Divided Into Three Groups; Group 1 Included 20 Children Received Oral Health Education And Topical Chlorhexidine Varnish And Group 2 Included 20 Children Received Oral Health Education And Topical Fluoridevarnish, While Group 3 Included 20 Children Received Oral Health Education Only. Salivary Samples Were Collected From Each Child At Baseline, One Day, Three Months, Six Months And Twelve Months After The Start Of The Study. At The Start Of The Study, Three Months And Six Months Later, Salivary Samples Were Prepared For Measuring Salivary PH And Streptococcus Mutants Counts And Scheduled Immediately Before And After Varnish Application. Statistical Analysis Used: All Test Statistics Were Performed Using The SPSS Package System V.22. Descriptive And Inferential Statistics Including ANOVA And Paired-t-test Were Used. Level Of Significance Used Was 0.05.

Results: It Was Noticed That Group I Who Received Chlorhexidine Varnish Had Improvement On Their Salivary Parameters During Follow Up Periods Until One Year, While Group II Who Received Fluoridevarnish Had Improvement On Their Salivary Parameters For A Short Period Of Time Only. Whereas The Results Of The Third Group Showed Deterioration Of Their Salivary Parameters.

Conclusions: Chlorhexidine Varnish Is Better Than Fluoridevarnish As It Improved Oral Health Of Leukemic Children By Raising Salivary PH, Reducing The Count Of Streptococcus Bacteria And Its Efficacycould Last For Long Period Of Time Until One Year. While Fluoridevarnish Could Produce The Same Effect For Short Period Of Time Only.