EDJ

AN IN-VITRO STUDY OF THE EFFECT OF EVEROLIMUS ON SQUAMOUS CELL CARCINOMA CELL LINE

Loay Abdellatef Mohamed, Amr Helmy Mostafa And Enas Alaaeldin Abdelaziz,

ABSTRACT

Objectives: The Purpose Of This Study Was To Evaluate The Effect Of Mammalian Target Of Rapamycin (mTOR) Inhibitor (everolimus) On Squamous Cell Carcinoma Cell Line.

Materials and Methods: Prepared Human Squamous Cell Carcinoma Cell Line (Hep-2) Was Treated With Different Concentrations Of Everolimus. The Effect Of Everolimus On Cell Line Was Investigated Using MTT Cytotoxicity Assay And Nuclear Morphometric Analysis

Results: The MTT Assay Showed That The Viability Of Everolimus Treated Hep-2 Cells Decreased As The Concentration Of Everolimus Increased From 8 To 500 NM With IC50 Being 132 NM. Morphometric Analysis Showed A Decrease In Nuclear Area Factor (NAF) Which Is An Indicator Of Apoptosis As Concentration Increased. Conclusion: The MTOR Inhibitor (everolimus) Has A Toxic Effect On Squamous Cell Carcinoma Cell Line.

ADVANCED SEARCH

	ROLE OF CONTINUING PROFESSIONAL DEVELOPMENT IN THE PROMOTION OF QUALITY OF DENTAL PRACTICE IN ALEXANDRIA EGYPT
	EFFICACY OF XP-ENDO FINISHER FILE VERSUS PASSIVE ULTRASONIC IRRIGATION IN REMOVING CALCIUM HYDROXIDE FROM ROOT CANALS WITH DIFFERENT IRRIGATING SOLUTIONS (AN IN VITRO STUDY)
	MICRO-TENSILE BOND STRENGTH OF NEW RESIN COMPOSITE RESTORATIVE MATERIAL TO DENTIN USING TWO DIFFERENT ADHESIVE SYSTEMS (IN-VITRO STUDY)
	HORIZONTAL RIDGE AUGMENTATION OF ATROPHIC MAXILLA USING XENOGRAFT BLOCK
	PREVALENCE OF SIGNS AND SYMPTOMS OF TEMPORO-MANDIBULAR JOINT DISORDER IN A SAMPLE OF EGYPTIAN ADOLESCENTS: A CROSS SECTIONAL STUDY
	IMPLANT PLACEMENT IN MAXILLA WITH SIMULTANEOUS SOFT TISSUE AUGMENTATION AND ITS EFFECT ON IMPLANT STABILITY. A CASE SERIES STUDY
	PATIENTS? ACCEPTANCE OF 3 DIFFERENT FACIAL SOFT TISSUE MEASURING TECHNIQUES
	EFFECT OF FLUORIDE LEVEL IN DRINKING WATER ON SKELETAL AND DENTAL FINDINGS IN A GROUP OF CHILDREN IN A RURAL AREA IN NUBIA
	CONVENTIONAL VERSUS COMPUTER GUIDED SURGICAL REMOVAL OF DEEPLY IMPACTED MANDIBULAR THIRD MOLAR (RANDOMIZED CLINICAL TRIAL)
	PATIENTS? ACCEPTANCE OF MODIFIED 3D PRINTED TWIN BLOCK APPLIANCE- A PILOT SURVEY

	THE EFFECT OF TWO FINISH LINE DESIGNS (FEATHER EDGE OR CHAMFER) ON THE FRACTURE RESISTANCE OF ZIRCONIA REINFORCED LITHIUM SILICATE (VITA SUPRINITY) CROWNS UNDER CYCLIC LOADING (IN-VITRO STUDY)
	RETENTION OF ESTHETIC EQUIPOISE CLASP VERSUS CONVENTIONAL CLASP IN BOUNDED REMOVABLE PARTIAL DENTURE CASES. (IN VITRO STUDY)
	EVALUATION OF BIOCOMPATIBILITY AND ANTIMICROBIAL EFFICACY OF TOTALFILL BIOCERAMIC SEALER AGAINST ENTEROCOCCUS FAECALIS, PORPHYROMONAS GINGIVALIS AND PORPHYROMONAS ENDODONTALIS IN COMPARISON TO AH PLUS SEALER. (AN IN VITRO STUDY) 2031
	SCHNEIDERIAN MEMBRANE ELEVATION AND AUGMENTATION WITH HYDROXYAPATITE NANO PARTICLES [NANOSTREAMS] VERSUS GRAFT LESS TENTING TECHNIQUE WITH SIMULTANEOUS IMPLANT PLACEMENT. RANDOMIZED CLINICAL TRIAL
	HARD TOOTH STRUCTURE INTEGRITY IN HIGH SODA DRINKS CONSUMERS WITH AND WITHOUT FLUORIDE MOUTH RINSE: A RANDOMIZED CONTROLLED CLINICAL TRIAL
	ASSESSMENT OF A NOVEL CERAMIC CONSERVATIVE ESTHETIC APPROACH FOR RESTORING MISSING ANTERIOR TEETH. (AN IN-VITRO STUDY) ?PART II? (MECHANICAL PREFORMANCE)
	INFLUENCE OF QUERCETIN ON SQUAMOUS CELL CARCINOMA CELL LINE (HEP-2). AN IN-VITRO STUDY
	EVALUATION OF TRANSLUCENCY, OF TWO TYPES OF GLASS CERAMICS (IN VITRO STUDY)
	THE RELIABILITY OF CONE BEAM COMPUTED TOMOGRAPHY CORRECTED GRAY VALUES COMPARED TO MULTISLICE CT HOUNSFIELD UNITS
	DETECTING THE AMOUNT OF PRODUCED DAMAGE FROM DIODE LASER DIFFERENT WAVELENGTHS OR POWERS ON THE COLLATERAL ORAL SOFT TISSUE IN THE BUCCAL MUCOSA OF WHITE RABBIT