Engy Saeed El-Khawaga, Dina Soliman Khater And Nermeen Raouf Ameen .,

ABSTRACT
Adenoid Cystic Carcinoma (ACC) Is The Third Most Common Malignant Salivary Gland Tumor, Cancer Stem Cells (CSCs) Are Defined Cells Within A Tumor That Possess The Capacity To Self-renew, CD133 (prominin-1) Is An Important Marker To Identify And Isolate CSCs. A Total Of 50 Archival Paraffin-embedded Specimens (10 Normal Salivary Gland Tissues, 10 Tubular, 10 Trabecular, 10 Cribriform And 10 Solid Cases) Were Collected. Sections Were Stained Immunohistochemically By CD133 Antibody And The Area Percent For Its Expression Was Evaluated By The Image Analyzer Computer System, It Was Found ThatCD133 Immunoexpressionhad High Significant Difference In Area Percent Values Between The Control Group And The Different Patterns Of ACC. CD133 Expression Significantly Increased In The Solid Pattern Compared To The Other Patterns. No Significant Difference Was Observed Between The Tubular And The Trabecular Patterns. In Conclusion, CD133 Was Detected In ACC And Its Expression Was Related To Poor Biological Behavior. It Could Be A Promising Target As Regards Anti-CSC Therapy. Keywords: Adenoid Cystic Carcinoma- CD133- Prominin1- Cancer Stem Cells.