Mostafa K. Abdo, Mohamed G. Elshal, Nessren M. Abd El-Rady And Wael M. Refai,

ABSTRACT
Objective: To Study The Effect Of Gentamycin (aminoglycoside) Antibiotic Administration On Orthodontic Tooth Movement.

Materials and Methods: The Study Was Conducted On Twenty Male Rabbits. They Were Divided Into Two Groups. Control Group In Which Only Orthodontic Tooth Movement (OTM) Was Conducted And The Gentamycin Group In Which Rabbits Were Given Gentamycin IM Injections In Regular Doses (3-5 Mg/kg/day) And OTM Was Conducted. Appliance Was Applied To The Lower Right Side. A Closed Coil Spring Was Connected Posteriorly To The First Premolar And Anteriorly To The Central Incisor. Animals Were Sacrificed After 21 Days. The Lower Right Halves Of The Mandible Of All The Animals Were Prepared For Specimen, Decalcified And Prepared For Histological Evaluation To Detect Changes In Osteoblastic And Osteoclastic Activity.

Results: There Were No Significant Changes In The Rate Of OTM Between Both Groups. Conclusion: Aminglycoside Antibiotics Are Safe To Be Administered During Orthodontic Treatment As They Do Not Alter The Bone Metabolism Yet Care Should Be Taken For Their Adverse Affect On The Kidneys.