Kareem Shafik Diab, Magdy Mohamed Mohamed Aly And Dalia Ali Ahmad Moukarab .,

ABSTRACT
Objective: The Purpose Of This Study Was To Evaluate And Compare The Regenerative Potential Of Platelet Rich Fibrin And Plasma Rich In Growth Factors In Regeneration Of Mechanically Removed Coronal Pulp In Mature Teeth Histologically. Methods: Pulpotomy Was Performed In 24 Teeth From 2 Dogs, And The Pulp Chambers Were Filled With The Following Materials: (a) Groups 1: Platelet Rich Fibrin PRF; (b) Groups 2: Plasma Rich In Growth Factors PRGF. After 14 Days (groups 1/14-2/14) And 35 Days (groups 1/35-2/35), The Animals Were Euthanized And The Pieces Containing The Teeth Were Removed And Processed For Histological Analysis.

Results: Dentine Bridge Was Not Observed. The Radicular Pulp Response In Group 1/14 And Group 2/14 Consisted Generally Of Blood Vessels Dilatation, Diffusion Of The Platelet Concentrates Components, Areas Of Vacuolation Of The Odontoblastic Layer, Areas Of Pulp Tissue Disintegration And Fibrosis While In Group 1/35 And 2/35 These Findings Were Less Prominent Except For Fibrosis And Calcified Tissue Formation. Conclusion: The Observations Of This Study Might Help Develop A Predictable, Safe, And Cost-effective Vital Pulp Therapy Strategy, However Further Long Term Investigation And Research Is Needed To Reach More Conclusive Results About Their Possible Application In Human Patients.