Yousra Khaled Mohamed Ezzat , Abeer Mahmoud Marzouk And Geraldine Ahmed .,

ABSTRACT


Introduction: Achieving Profound Pulpal Anesthesia In Teeth With Irreversible Pulpitis Is Quite Challenging And Sometimes Difficult. This Study Evaluated The Efficacy Of Selective COX-2 Inhibitors As Premedication In Controlling Intra-operative And Post-endodontic Pain After Single Visit Endodontic Treatment Of Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis As Compared To Placebo. Methods: In A Randomized Double-blinded Clinical Trial, 46 Patients (23 Per Group) With Irreversible Pulpitis Were Given 200mg Celebrex, Or Placebo 1 Hour Before Local Anesthesia. Each Patient Recorded Their Pain Score On A Visual Analog Scale Before Taking The Medication, During Access Cavity Preparation And During Root Canal Instrumentation. No Or Mild Pain At Any Stage Was Considered A Success. Data Were Analyzed By The Mann-Whitney U Test For Comparison Between The Two Groups And Analysis Of Variance Tests.

Results: There Was A Statistical Gradual Reduction Of Pain In Both Groups Through All Time Intervals. At 12 Hours Post-operatively, Celebrex Group Showed Statistically Significant Higher Percentage Of Pain Reduction As Compared To The Placebo Group (p< 0.05). Regarding Long Buccal Infiltration And Intra-pulpal Anesthesia, Celebrex Group Showed Significantly Lower Percentage Of Using Supplemental Anesthesia (p=0.008).

Conclusions: Premedication With 200mg Single Dose Celebrex Prior To Initiation Of Endodontic Treatment Augmented The Effect Of Inferior Alveolar Nerve Block And Has A Satisfactory Effect On Reduction Of Post-operative Pain.