Mahmoud Elshahat Mohamed, Heba Elsayed And Nahed Aboazma .,

ABSTRACT
Oral Squamous Cell Carcinoma (OSCC) Is A Characteristic Aggressive Tumor Representing A Significant Public Health Threat All Over The World. Oral Verrucous Carcinoma (OVC) Is An Uncommon Rare Low-grade Variant Of Well Differentiated OSCC, Which Accounts For 2-10% Of All Oral Carcinomas. Thrombospondin-1 (TSP-1) Is An Extracellular Matrix (ECM) Protein That Participates In Cellular Responses To Growth Factors, Cytokines And It Regulates Cell Proliferation, Migration And Apoptosis.

Aim: This Work Aimed To Assess The Relation Of TSP-1 Expression To Biological Behavior Of OSCC And OVC.

Materials and Methods: Forty Paraffin-embedded Specimens Divided Into 30 Cases Of OSCC And 10 Cases Of OVC Obtained From The Archives Of Oral Pathology Department, Faculty Of Dentistry, Tanta University.

Results: This Study Revealed That TSP-1 Expression In Stromal Cells, There Was A Significantly Higher Expression In Moderately And Poorly Differentiated OSCC In Comparison To Well Differentiated Ones. While TSP-1 Expression Was Weak In Well Differentiated OSCC And OVC.