Nihal Mohamed Darwish , Safa Fathy And Heba Mahmoud Dhmoush,

ABSTRACT
Background: BPs Have Been Widely Used For The Management Of Osteoporosis. Since Tooth Extractions Are Common Dental Procedures In The Elderly, Therefore, It Is More Crucial For Dentists To Understand The Effect Of BPs On Tooth Extraction Wound Healing To Establish Better Informed Postextraction Care. This Study Was Aimed To Assess The Impact Of Oral And The Intravenous Administration Of Bisphosphonates On Bone Healing After Tooth Extraction And Compare The Histopathological And Radiographic Density Of The Alveolar Bone Associated With Both Ways Of Administration.

Materials and Methods: 52 Rats Were Used In The Present Study, Divided Into 3 Groups. Control Group (10 Rats With No BPs Therapy), Oral Group {21 Rats Who Received Oral BPs (Fosamex, 0.21mg/day) And Intraperitoneal Group ( 21 Rats Who Received IV BPs (Zometa, 0.01 Mg IP Injection Once) Then After 1 Week Of Drug Administration, The First Lower Left Molar Of All Groups Was Extracted. Rats Were Killed After 2, 4 And 6 Weeks From Extraction And The Dissected Mandibule Was Evaluated Histologically And Radiographically (table 1).

Results: In The Extraction Side, The IPG Showed More Increase In The Bone Density In The 2 And 4 Week Interval Than The NCG And The OG However, BRONJ Was Significantly Higher In The 6 Week Interval Of The IPG. In The Non- Extraction Side The Area% Of The Bone In The 3 Groups Was Close In The 2 And 4 Week Intervals But Deterioration Of The Bone Condition Was Seen In The OG And The IPG At 6 Week Compared To NCG. Conclusion: IV BPs Show Rapid Initial Increase In The Bone Density More Than The Oral BPs However On The Long Term It Results In Delayed Healing Of Extraction Socket And Decrease Bone Density.