Samah Lotfy Abd-Elmoula Korshom, Ebtesam Abd Khalek EI-Zefzaf , Sahar Fawzy Ghoraba , And Sahar Mohey Eldin Hazzaa ,

Oral Lichen Planus (OLP) Is A Chronic Inflammatorycondition Implicating T Cell-mediated Cytotoxicity, And Involving Oral Mucosal Surfaces.Aim Of Work: To Evaluate Clinically And Immunologically The Effect Of Diode Laser Versus Topical Corticosteroid Mouthwash In The Management Of Patients With Atrophic-erosive OLP.Materials And Method: 20 Patients Suffering From OLP Were Randomly Assigned Into 2 Group. Group I: Ten Patients Received LLLT By Using Diode Laser Irradiation 808 Nm Wave Length, Group II: (Control Group) Ten Patients Treated By Topical Corticosteroids Consisting Of Dexamethasone Mouthwash For 5 Minutes, Followed 30 Minutes Later By A Mouth Rinse With 30 Drops Of Nystatin (100,000 Unites) For 5 Minutes. The Evaluation Was Assessed Clinically Via Measuring Pain Score And Size Of Lesion And Lesion Recurrence, And Immunologically By Measuring IL-6 Cytokine Level In Saliva.

Results: Corticosteroids Group Showed Better Pain Reduction Than LLLT, With No Statistically Significantdifference In The Mean Value Level Of IL-6 Level At Base Line, But At 4th Week, 1st Month, 2nd Month And 3rd Month Results Revealed Statistically Significantdifference Between G I And GII (p? 0.05).Conclusion: The Results Have Shown That LLLT Was Effective In Management Of Atrophic - Erosive OLP And It Can Be Considered As An Alternative Treatment. However, Traditional Corticosteroid Therapy Showed Better Results.