EDJ

ASSESSMENT OF CYTOKERATIN 19 AND ITS SOLUBLE SALIVARY FRAGMENT CYFRA 21-1 IN BENZANTHRACENE INDUCED DYSPLASIA AND TONGUE SQUAMOUS CELL CARCINOMA IN RATS

Hala Khaled Elsayed; Amal Hassan Abdel-Rahman And Dina Soliman Khater,

ABSTRACT
Background: Head And Neck Cancer Among The Most Common Incident Cancers In Men Worldwide.?Early Detection Is The Key To Higher Survival Rate Against This Type Of Cancer. Cytokeratins Are Essential Intracellular Components, Reflecting Distinct Cellular Properties And Differentiation Stages In Epithelial Tissues. The CYFRA 21-1 Assay, Which Is The Soluble Fragment Of Cytokeratin 19, Has Been Proven Capable Of Early Detection Of Epithelial Carcinomas. This Study Was Conducted To Correlate The Immunoexpression Of CK 19 With The Concentration Of Its Salivary Fragments (CYFRA 21-1) For Early Detection Of Induced Dysplastic Changes Prior To Malignant Transformation In Experimental Rat. Conclusion: There Is A Positive Correlation Between CK 19 Immunoexpression In Tissue And The Level Of CYFRA 21-1 In Saliva.

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