Hassan Mohamed Salah ; Manal Mohamed Hosny; Olfat Gameel Shaker And Rasha Wagih Mostafa,

ABSTRACT

Objectives: The Aim Of The Present Study Was To Evaluate The Possible Effect Of Vitamin E Administration As An Adjunct To Scaling And Root Planing On GCF Levels Of Malondialdehyde And Clinical Parameters In Patients With Chronic Periodontitis. The Adjunctive Effect Of Vitamin E Was Compared To Scaling And Root Planing Alone. Methods: Thirty-two Patients With Chronic Periodontitis Participated In This Study. They Received Scaling And Sub Gingival Debridement With Either Administration Of Vitamin E (Group I) Or Placebo (Group II). The Primary Outcome Was To Measure The Level Of Malondialdehyde (MDA) In Gingival Crevicular Fluid (GCF) Using The Quantitative Sandwich ELISA Technique. In Addition, Clinical Parameters Such As PLI,GI, PPD And CAL Were Recorded At Baseline And 3 Months After Treatment. Results The Mean Difference Between Baseline And 3 Months Scores Presented Significant Difference Between The 2 Groups With Respect To CAL And PD. The Test Group Presented More Gain In CAL (0.78mm Versus 0.46mm) And More Reduction In PD (0.81mm Versus 0.41mm). The Test Group Presented Higher Reduction In GCF Level Of MDA 3 Months Posttreatment. However, The Difference Between Groups Did Not Reach Statistical Significance. Conclusion: Scaling And Root Planing Significantly Reduced GCF Levels Of MDA 1 And 3 Months After Treatment Compared To Baseline Values. The Adjunctive Administration Of Vitamin E Produced Higher Reduction In GCF Levels Of MDA 3 Months After Treatment In Comparison To Control Group. The Adjunctive Administration Of Vitamin E Produced More Significant Reduction In Full Mouth Scores For PD And More Significant Gain In Full Mouth Scores For CAL 3 Months After Treatment.