Esmat A.G, El-Sharaby F.A And El-Ezz A.A,

ABSTRACT
Background: Patients Rank Pain As The Worst Aspect Of Orthodontic Treatment, And It Is The Foremost Reason For Wanting To Terminate The Treatment. Pain And Discomfort Are Of High Prevalence During Fixed Orthodontic Treatment And Are Reported To Occur In 91?95% Of Patients. Orthodontic Patients Expressed Feeling Pain During And After Several Procedures As Separator Placement And Initial Archwire Placement. These Side Effects May Discourage Patients Or Reduce Their Compliance During The Course Of Treatment. Orthodontic Pain Reaches Its Peak Intensity At 24 Hours Or 1 Day After Force Application And Lasts For The Following One Week. Analgesics Such As Acetaminophen And Ibuprofen Remain The Most Preferred And Most Commonly Used Method For Managing Orthodontic Pain. Objectives : The Aim Of This Study Was To Compare The Analgesic Effectiveness Of Ibuprofen Versus Paracetamol During The Initial Stages Of Fixed Orthodontic Treatment And Evaluate Their Effect On The Rate Of Tooth Movement Through The Performance Of A Systematic Review To Search And Critically Appraise The Quality Of The Evidence Available, Based On A Sound Inclusion And Exclusion Criteria.

Results: Eleven Articles Were Eligible For Qualitative Analysis While Eight Were Eligible For The Quantitative Analysis (531 Participants). Meta-analysis Using The Random Effects Model To Evaluate The Standard Mean Difference (SMD) With Level Of Significance Set At P?0.05 Was Performed To Evaluate The Analgesic Effect Of Ibuprofen And Acetaminophen At 2,6 And 24 Hours. The Results Showed Insignificant Differences Between The 2 Drugs In All Of The Studied Primary Outcomes. Conclusion: The Currently Available Evidence Was Insufficient To Form A Definitive Conclusion Regarding The Effectiveness Of Ibuprofen Versus That Of Paracetamol In Managing Orthodontic Pain And Their Effects On The Rate Of Tooth Movement. Ibuprofen Mean Pain Scores Were Lower Than That Of Acetaminophen But They Were Not Statistically Significantly Different From That Of Acetaminophen