Mostafa A. Nafie, Amal A. Hussine And Fat?heya M Zahran,

ABSTRACT
Background: Recurrent Aphthous Stomatitis (RAS) Affects 20% Of The Population And Is Currently One Of The Most Common Oral Disorders. It Is An Inflammatory Condition Of Unknown Etiology Characterized By Recurrent, Painful, Single Or Multiple Ulcerations Of The Oral Mucosa. Various Treatment Modalities Such As Anti-inflammatory Agents, Steroids, Sucralfate, Tetracycline Suspension, Analgesics, Anesthetics, Antiseptics And, Recently, Anti-oxidants Are The Standard Topical Treatment Options That Provide Symptomatic Relief.

Aim: The Aim Of The Present Investigation Is To Evaluate The Clinical Effectiveness Of Coenzyme Q10 (CoQ10) Gel As An Anti-oxidant In The Management Of Idiopathic Recurrent Minor Oral Aphthous Ulcers In Patients Free From Any Systemic Condition. Subjects And Methods: The Present Study Was Conducted On 52 Patients (33 Males And 19 Females) Suffering From Symptomatic Oral Minor Aphthous Ulcers. Patients Were Randomly Divided Into Two Groups, One Of Them; The Intervention Group (A), Received Topical CoQ10 Gel In A 2% Concentration And The Other; Control Group (B), Received Carbopol Gel As Placebo. Each Group Contained 26 Patients (14 Males And12 Females In Group A And 19 Males And 7 Females In Group B) Who Were Instructed To Use Topical Oral Gel Delivered To Them In Sealed Opaque Jars, 2 Times /day After Breakfast And Evening Meals. Patients Were Evaluated At Initial Visit Day (day 0), Day 4 And Day 7, Using The Clinical Parameters Of Pain Score (VAS), Ulcer Size, Erythema Score And Healing Period.

Results: There Were Significant Differences In Reduction Of Pain, Size, Surrounding Erythema And Healing Period Of Ulcer Between The 2 Groups At Different Follow-up Intervals Within A Period Of 7 Days. Group A Showed Higher Significant Reduction In Pain, Ulcer Size And Erythema Compared With Group B Which Was Evident At 4th Day. Concerning The Healing Period, There Was Significant Difference Between Both Groups With P Value <0.001 In Favor Of Group A. Conclusion: Based On The Results Of The Current Study Co Enzyme Q10 Can Be Used As An Effective And Safe Agent In The Management Of RAS, Providing A Significantly Shorter Healing Period.