Hanan M. Abdullah , Laila S. Ghali And Radwa H. Hegazy ,
ABSTRACT
The Present Investigation Aimed To Find Out The Impact Of The Diuretics On The Histological Structures Of The Gingival Mucous Membranes And The Immunohistochemical Localization Of The Proliferating Cell Nuclear Antigen In The Aforementioned Structures. Thirty Adult Male Albino Rats With Average Body Weight 150 ? 10 Grams Were Divided Into Three Groups, 10 Animals Each. Group I, Served As Controls. Animals Received In Group II Acetazolamide (Diamox) In A Daily Oral Dose Of 8 Mg, And Furosemide (Lasix) In A Daily Oral Dose Of 40 Mg In Group III. The Specimens Were Processed To Be Embedded In Paraffin And Stained With Hematoxylin And Eosin For The Mucous Membrane Of Gingiva And PCNA Mouse Monoclonal Antibody For The Proliferating Cell Nuclear Antigen. The Results Revealed That Furosemide, Though Often Effective For Treating Hypertension, Should Have Significant Limitations Due To The Currently Reported Degenerative And Atrophic Changes Shown In The Gingiva. Acetazolamide, One Of The Carbonic Anhydrase Inhibitors Had The Least Degenerative Effects But Is A Weak Diuretic.