Ehab Magdy Shafik, Sherif Farouk El-gayar, Enas Alaa El-din Abd El-Aziz And Hanan Eid Gamal .,
ABSTRACT
Aim Of Study: To Evaluate The Anticancer Potential Of Propolis On Human Laryngeal Squamous Cell Carcinoma Cell Line (Hep-2).
Materials and Methods: Prepared (Hep-2) Cell Line Was Treated With Different Concentrations Of Propolis For 24 Hours. The Effect Of Propolis On Cell Line Was Investigated Using MTT Assay, Cytological Examination And Nuclear Morphometric Analysis. The Results Were Analyzed Statistically.
Results: MTT Assay Showed That The Mean Viability Percentage Of Propolis Treated Cells (in Relation To Control Cells) Decreased As Propolis Concentration Increased From 0.275mg To 280mg. Morphometric Analysis Showed A Decrease In Nuclear Area Factor (NAF) Which Is An Indicator Of Apoptosis As Concentrations Increased. The Results Were Statistically Significant.
Conclusion Propolis Has A Significant Anticancer Effect On Hep-2 Cell Line.