Maie Hamdy Elakkad; Manal Mostafa ElAssaly And Heba Mohamed Hakam,

ABSTRACT
This Research Was Designed To Compare The Efficacy Of Local Irrigation Of Simvastatin (SIM) In The Relief Of The Symptoms Accompanying Pericoronitis Versus Normal Saline Solution.

Materials & Methods: 30 Male Volunteers, Age 18-28 Years Old Suffering From Pericoronitis Were Divided Into 3 Groups 10 Volunteers Each: Group 1 (Control): Where Immediate Operculectomy Was Done, Group 2 (experimental): Who Received Normal Saline Solution Irrigation & Group 3 (experimental): Received Irrigation Of Prepared SIM Solution. Operculectomy Was Performed On The 2nd And 4th Days Post Irrigation For 5 Volunteers Each Time In Both Groups 2 & 3. Excised Opercula Were Examined Both Histologically & Immunohistochemically For Localization Of TNF-� & BMP-2.

Results: Histological Examination Revealed That Both Normal Saline And Simvastatin Solution Improved The Histological Signs Of Inflammation With Superior Results Of The Later. The Highest Mean Value Of TNF-� Was Found In Group 1 (control) (38.98 � 7.60) While The Least Mean Value Of TNF-� Was Found In Group 3 (experimental) (3.15 � 1.34) After 4 Days Of Simvastatin Irrigation. The Highest Mean Value Of BMP-2 Was Found In Group 3 (experimental ) (31.95 � 7.61) After 4 Days Of Simvastatin Irrigation While The Least Mean Value Of BMP-2 Was Found In Group 1 (control) (9.26 � 1.72). Conclusion: Irrigation Using Simvastatin Solution Was More Effective Than Normal Saline On Both Histological& Immunohistochemical Levels.