Arzaq Sami Abdulrazzaq, Mohamed Abdul Magied Katamish And Amr Amin Ghanem,
ABSTRACT
Objective: The Aim Of This Study Was To Evaluate The Effect Of Mesenchymal Stem Cells In Healing Of Segmental Bony Defects.
Materials and Methods: The Study Was Conducted On Sixteen Skeletally Mature New Zealand Rabbits Weighing 2 To 2.5 Kg. An Approximately 5 Mm Segmental Defect Was Created In The Tibia Of The Animals After The Fixation Of The Tibia With Plate And Screws. We Injected MSCs Into The Defects In The Study Group While The Defects Of The Rabbits Of The Control Group Were Left Empty. All Of The Animals Were Sacrificed On Postoperative Day 22. Digital Radiodensitometric Analysis, Histologic And Histomorphometric Examinations Were Performed On The Harvested Tibia. The Data Were Statistically Analyzed.
Results: There Was Highly Significant Difference Between MSCs Group And Control Regarding Bone Density, Trabecular Bone Thickness And Area Percentage Of Osteoid Tissue.
Conclusion: MSCs Showed Promising Results In Improving The Healing Of Segmental Bone Defects In Macroscopic And Microscopic Levels.
