Mohamed M. Ammar, Gihan H. Waly, Sayed H. Saniour And Taheya A. Moussa,

ABSTRACT
The Aim Of This Study Is To Develop An Injectable Thermo-sensitive Hydrogel Loaded With Freeze-dried Platelet Concentrate And To Characterize This Hydrogel Regarding Its Gel Formation, Biodegradation And Rheological Properties. A Thermo-sensitive Chitosan-based Hydrogel Was Prepared And Its Biodegradation Rate Was Investigated. The Hydrogel Was Loaded With Freeze-dried Platelet Concentrate (FDPC) At Different Concentrations (5 Mg/ml, 10 Mg/ml And 15 Mg/ml) And The Viscosity Of The Unloaded And Loaded Hydrogel Was Investigated As The Temperature Was Raised From 25�C To 37�C. Results Showed That The Hydrogel Lost About 35% Of Its Weight During 32 Days. All FDPC-loaded Hydrogel Groups Showed Lowered Initial Viscosity Of The Hydrogel But FDPC Didn?t Affect The Sol-gel Transition In Any Group In Comparison To The Unloaded Control Group. Accordingly, It May Be Concluded That FDPC Can Be Loaded Within A Thermo-sensitive Hydrogel That Offers The Ease Of Application And Delivery Of Platelet Concentrate Which Can Be Beneficial In Periodontium Regeneration.