EDJ

EVALUATION OF THE ANTICANCER POTENTIAL OF SNAKE VENOM (NAJA HAJE) ON HEAD AND NECK SQUAMOUS CELL CARCINOMA CELL LINE

Sabreen Gamal Khalil, Amr Helmy El-Bolok, Sherif Farouk El-gayar, Maii Ibrahim Solkamy And Enas Alaa Eldeen Abd Elaziz,

ABSTRACT
Aim Of Study: To Evaluate The Anticancer Potential Of N. Haje Venom On Head And Neck Squamous Cell Cancer (HNSCC) Cell Line (HEp-2).

Materials and Methods: Prepared (HEp-2) Cell Line Was Treated With Different Concentrations Of N. Haje Venom For 24 Hours. The Effect Of N. Haje Venom On Cell Line Was Investigated Using MTT Assay, Cytological Examination, And Nuclear Morphometric Analysis. The Results Were Analyzed Statistically.

Results: The MTT Assay Showed That The Viability Of HEp-2 Cells Decreased As N. Haje Venom Concentrations Increased With Pre IC50 =25�g/ml, IC50= 60.32�g/ml And Post IC50= 80�g/ml. Morphometric Analysis Showed A Decrease In Nuclear Area Factor (NAF) Which Is An Indicator Of Apoptosis As Concentrations Increased. The Results Were Statistically Significant P Value 0.0001. Conclusion: N. Haje Venom Has A Significant Anticancer Effect On HEp-2 Cell Line.

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