Mona Sabah Farag El-Masry, Emad Tawfik Daif And Gamal M. Moutamed,

ABSTRACT


Aim: The Aim Of This Study Was To Assess The Effects Of Local Platelet Rich Plasma (PRP) Delivery On Mandibular Fracture Healing.

Materials and Methods: Patients Were Divided Into Two Equal Groups, 10 Patients Each. Under General Anesthesia, Mandibular Fractures Of Patients In Study Group (A) Were Treated By Open Reduction And Internal Fixation Using The Conventional Miniplate System With Local Application Of Activated PRP Along The Fracture Line. While Mandibular Fractures Of Patients In The Control Group (B) Were Treated By The Same Surgical Approach Of Open Reduction And Internal Fixation Using A Conventional Miniplate System Without Local Application Of PRP. Then Post-operative Digital Panoramic Radiographs Were Made For Each Patient At Four Postoperative Intervals; One Week And One, Three, And 6 Months Postoperative.

Results: Clinical Assessment After Surgery Showed That Oral Mucosa Healed Faster In Patients Of Study Group Than Those Of The Control Group Because Of The Stimulatory Effect Of Platelet-derived Growth Factors On Repair Of The Soft-tissue Wounds. The Changes In Optical Density Measurements On The Digitized Panoramic Views Were Recorded Using Digora Software And Then Analyzed. There Was No Statistically Significant Difference Between Bone Density Measurements Of The Two Groups At Each Interval. However, There Was A Statistically Significant Increase In Mean Bone Density Measurements At One Week And 1, 3 And 6 Months Post-operative In Both Study And Control Groups.