Dina Kamal , Dina Elkassas And Heba Hamza,

ABSTRACT

Objectives: Investigate The Efficacy Of Biomimetic Self-assembling Peptide (P11-4) On Enamel Remineralization Compared To Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACPF) And Fluoride Based Delivery Systems. Methods: Artificially Demineralized Enamel Windows Were Created On The Buccal Surfaces Of Forty Extracted Human Molars.. Specimens Were Randomly Assigned To 4 Groups (n=10) According To The Remineralizing Agent Used: G1- (Control, Artificial Saliva), G2- (Fluoride Varnish), G3-(CPP-ACPF Varnish), G4-(Self-assembling Peptide Agent).. All Products Were Applied According To The Manufacturer�s Instructions And Specimens Were Stored In A Daily Renewed Artificial Saliva. Surface Microhardness (SMH) Was Assessed At Baseline, After Demineralization, After 1 Week And 4 Weeks Remineralization.

Results: Self-assembling Peptide Showed The Highest Statistically Significant SMH Followed By Fluoride And CPP-ACPF While The Lowest SMH As Found In Artificial Saliva. However, No Statistically Significant Difference Was Found Between Fluoride And CPP-ACPF. Higher Statistically Significant SMH Was Found After 4 Weeks Compared To 1 Week Remineralization In All Groups.

Conclusions: Self-assembling Peptide Confers The Highest Remineralizing Efficacy Compared To Fluoride And CPP-ACPF; Showing A Promising, Non-invasive Regeneration Potential. Also, Extended Period Of Time Helped To Attain More Benefits From The Remineralizing Regimens Applied.