Nouran A Mohamed, Rehab F Fathi And Houry M Baghdadi,
ABSTRACT
Aims And
Objectives: This Study Aims To Analyse Immunohistochemically The Expression Of Sonic Hedgehog (Shh) In Oral Epithelial Dysplasia (OED) And Oral Squamous Cell Carcinoma (OSCC).
Methods: Fifty Formalin-fixed, Paraffin-embedded Specimens Of OED And OSCC, Twenty Diagnosed As OED And Thirty Diagnosed As OSCC, Were Included In The Present Study. Immunohistochemical Staining With Anti-Shh Primary Antibody Was Performed. Area Fraction Of Immunopositivity Was Estimated By Image Analysis Software.
Results: The Study Showed That Shh Signaling Molecules Are Highly Expressed In OED And OSCC.
Conclusion: Over-expression Of Shh Is Found In OED And OSCC And Might Be Used As
A Reliable Diagnostic Marker For Both Cases.
