Ahmed Helmy Salama, Moushira Dahaba, Amira Fares And Mohamed Sherif,

ABSTRACT
Objective: The Aim Of The Present Work Was To Study The Effect Of Anticancer Drugs On Enamel Structure, Using Scanning Electron Microscope And Digora X-ray System. Material & Methods: 30 Male Albino Rats, Aged 30 Days And Weighing 80 G Each Have Been Used In This Study, They Were Divided Into 3 Groups (10 Rats Each), Group I (control), Group II (vinblastine Group) And Group III (Taxotere Group). Vinblastine And Taxotere Were Given As A Single Intravenous Dose (4 Mg/kg) Via The Tail Vein. All Groups Were Further Subdivided Into 2 Subgroups A And B (5 Rats Each) And Were Sacrificed After 1 And 3 Weeks Respectively By Carbon Dioxide Inhalation. In Each Specific Time, The Mandible From Each Rat Was Removed And Sectioned Into Two Halves. The Incisors Cleaned Gently By Water For A Few Seconds. From Gingival Margin, Segment Of Lenght 2.8 Mm Were Measured And Dissected, Which Represent The Erupted Part Per Week. The Same Was Done For Three Weeks Groups. The Specimens Were Examined By Scanning Electron Microscope From Both Surface And Cross Section For Evaluating The Morphological Changes In The Enamel Surface And By Digora X- Ray For Evaluating The Enamel Density Of The Experimental Groups.

Results: Scanning Electron Microscope Of The Both Vinblastine And Taxotere Groups Revealed That, Variable Defective Pattrens In One-week Subgroup The Enamel Surface Showed Different Defects As Honeycomb Pattern, Variable Size Globules And Cracks. While In Three Weeks Subgroup The Enamel Surface Showed Larger Defects As Increase In The Honeycomb Pattern And More Pronounced Cracks. Statistical Analysis Results Of The Digora X Ray Measurements Revealed That, A Statistically Significant Difference Between The Control Group And The Both Vinblastine (one & Three Weeks) And Taxotere (one & Three Weeks) Subgroups. Conclusion: Both Vinblastine And Taxotere Caused Morphological Defects In The Enamel Structure. Both Drugs Caused Reduction In The Enamel Density. Vinblastine Causes Decrease In Enamel Density More Than Taxotere As Revealed By Digora X Ray System.