A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: Cannot modify header information - headers already sent by (output started at /home1/ab8102/public_html/edjcode/system/core/Exceptions.php:271)
Filename: core/Security.php
Line Number: 274
Backtrace:
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$hooks is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$config is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$log is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$uri is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$router is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$output is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$security is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$input is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$lang is deprecated
Filename: core/Controller.php
Line Number: 75
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$load is deprecated
Filename: core/Controller.php
Line Number: 78
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 129
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 280
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 151
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 208
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 297
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_database_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_database_driver.php
Line Number: 335
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 7
Function: __construct
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Javascript::$CI is deprecated
Filename: libraries/Javascript.php
Line Number: 81
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Jquery::$CI is deprecated
Filename: Javascript/Jquery.php
Line Number: 110
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: strpos(): Passing null to parameter #1 ($haystack) of type string is deprecated
Filename: libraries/Javascript.php
Line Number: 657
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$jquery is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Javascript::$js is deprecated
Filename: libraries/Javascript.php
Line Number: 86
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$javascript is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 9
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 10
Function: library
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$mode is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 13
Function: model
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Edj::$Image_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 14
Function: model
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$security is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$input is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$lang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$db is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$session is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$jquery is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$javascript is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$form_validation is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Loader::$mode is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home1/ab8102/public_html/edjcode/application/controllers/Edj.php
Line: 139
Function: view
File: /home1/ab8102/public_html/edjcode/index.php
Line: 315
Function: require_once
A PHP Error was encountered
Severity: 8192
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EDJ
THE EFFECT OF BISPHOSPHONATES AND ANTIOXIDANTS ON BONE HEALING- EXPERIMENTAL STUDY
,
Volume 1 No 1
223
Hisham A. A. Qais, Hamdy A. M. Marzook And Rehab Rizk Abas El Zehary ,
ABSTRACT
Objectives: This Study Was Designed To Evaluate The Influence Of Bisphosphonates And Antioxidants On Bone Healing Histologically After Surgical Defect Of Bone Tissue In Rabbits.
Methods: A Total Of 60 Rabbits Were Randomly Divided Into Three Main Equal Groups: One Control Group And Two Study Groups. Three Circular 5 Mm Diameter Bony Defect Were Subjected At The Medial Surface Of The Proximal Right Tibia Using A Trephine Bur. The Bone Defects Were Left Empty (control Group, N = 20), Animals Were Treated With 0.1 Mg/kg Zoledronic Acid (Zometa) (study Group 1,
N = 20), Treated With 0.1 Mg/kg Zoledronic Acid (Zometa) And Vitamin C (Cevarol) (study Group 2,
N = 20). Each Group Was Divided Into 4 Subgroups (A, B, C, And D) According To The Period At Which The Animals Were Sacrificed (1, 3, 5, And 7 Weeks Respectively) For The Study And Control Groups.
The Specimens Were Evaluated By Histology And Histomorphometric Analysis.
Results: There Were Highly Significant Differences Between The Groups Regarding To Amount Of Bone Formation At Different Periods Of Follow Up Either 1st, 3rd, 5th, Or 7th Weeks (P ? 0.001). Also, There Were Significant Differences Between Intra- Group Distributions Concerning To Amount Of Bone Formation At Different Periods Of Follow Up Either 1st, 3rd, 5th, Or 7th Weeks ( P1, P2, And P3 ? 0.001).
Conclusion: In The Current Study It Was Found That, Proper Application Of Bisphosphonates And Antioxidants Managements, A Positive Improvement On Bone Tissue Healing Occurred.
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