Sara Mohamed Mahmoud, Khaled Ezzat And Shaimaa Ismail Gawdat,

ABSTRACT
Aims This Prospective, Randomized, Double-blind Clinical Trial Was Aimed To Compare The Efficacy Of 2% Mepivacaine With 1:100,000 Epinephrine To 4% Articaine With 1:100,000 Epinephrine For Inferior Alveolar Nerve Block (IANB) In Patients With Symptomatic Irreversible Pulpitis In Mandibular Molars. Methodology Sixty Six Patients Diagnosed With Symptomatic Irreversible Pulpitis In Mandibular Molar Teeth Were Randomly Allocated To One Of Two Equal Groups To Receive 3.6 ML Of 2% Mepivacaine (2 Carpules) Or 3.4 ML Of 4% Articaine (2 Carpules) Both With 1:100,000 Epinephrine, Using A Conventional IANB Technique. Endodontic Access Cavities Were Prepared 15 Minutes After Solution Deposition, And All Patients Were Required To Have Profound Lip Numbness. Success Was Defined As No Or Mild Pain (numerical Rating Scale Recording) Upon Endodontic Access Cavity Preparation Or Initial Canal Instrumentation And The Patients Who Needed Supplemental Anesthesia Were Counted. Finally, The Collected Data Were Subjected To Independent T-test, Chi-square And Fisher?s Exact Test By Using SPSS Software At A Significant Level Of 0.05. Results The Success Rates For IANB Using Mepivacaine And Articaine Were 30% And 33%, Respectively, Where Both Groups Showed No Statistically Significant Difference. Similarly There Was No Statistically Significant Difference In The Need For Supplemental Anesthesia In Both Groups Conclusion For Mandibular Molars With Symptomatic Irreversible Pulpitis Anesthetic Efficacy Of 2% Mepivacaine Was Similar To That Of 4% Articaine (both With 1:100,000 Epinephrine) In Inferior Alveolar Nerve Blocks And Neither Of Anesthetic Solutions Resulted In Effective Pulpal Anesthesia During Endodontic Treatment.