Hisham A. A. Qais, Hamdy A. M. Marzook And Rehab Rizk Abas El Zehary,

ABSTRACT

Objectives: This Study Was Designed To Evaluate The Influence Of Bisphosphonates And Antioxidants On Bone Healing Histologically After Surgical Defect Of Bone Tissue In Rabbits. Methods: A Total Of 60 Rabbits Were Randomly Divided Into Three Main Equal Groups: One Control Group And Two Study Groups. Three Circular 5 Mm Diameter Bony Defect Were Subjected At The Medial Surface Of The Proximal Right Tibia Using A Trephine Bur. The Bone Defects Were Left Empty (control Group, N = 20), Animals Were Treated With 0.1 Mg/kg Zoledronic Acid (Zometa) (study Group 1, N = 20), Treated With 0.1 Mg/kg Zoledronic Acid (Zometa) And Vitamin C (Cevarol) (study Group 2, N = 20). Each Group Was Divided Into 4 Subgroups (A, B, C, And D) According To The Period At Which The Animals Were Sacrificed (1, 3, 5, And 7 Weeks Respectively) For The Study And Control Groups. The Specimens Were Evaluated By Histology And Histomorphometric Analysis.

Results: There Were Highly Significant Differences Between The Groups Regarding To Amount Of Bone Formation At Different Periods Of Follow Up Either 1st, 3rd, 5th, Or 7th Weeks (P � 0.001). Also, There Were Significant Differences Between Intra- Group Distributions Concerning To Amount Of Bone Formation At Different Periods Of Follow Up Either 1st, 3rd, 5th, Or 7th Weeks ( P1, P2, And P3 � 0.001). Conclusion: In The Current Study It Was Found That, Proper Application Of Bisphosphonates And Antioxidants Managements, A Positive Improvement On Bone Tissue Healing Occurred.