Hanan A. Abushawaly, Basma G.Moussa, Heba M. Kamel And Dawlat E. Gomaa,

ABSTRACT
The Main Objective For Conducting This Study Was To Evaluate The Effect Of PRF On Wound Healing After Surgical Repair Of Cleft Palate, How It Could Decrease Incidence Of Fistula And To Show If It Had A Noticeable Role In Minimization Of The Post-operative Bleeding. One Case Of The Control Group Showed Wound Dehiscence. However, Post-operative Healing Between The Two Groups Was Statistically Insignificant. Amount Of Postoperative Bleeding Was Insignificant; It Was Mostly Related To The Extent Of The Surgical Field And Time Of Surgery.

Amr Helmy Moustafa El Bolok, Safaa M. Tohamy, Hanan Eid Gamal, Enas Alaa Eldin And Basma Mahmoud Ryad,

ABSTRACT
Background: Quercetin Is An Effective Cytotoxic Anticancer Agent And Has Been Used For The Treatment Of Variety Of Malignancies. The Aim Of The Current Study Is To Investigate The Influence Of Quercetin On Squamous Cell Carcinoma Cell Line (HEP-2) After 24 Hours. Material & Methods: Treatment Of Cell Line (HEp-2) By Different Concentrations Of Quercetin Was Done To Assess The Viability Of The Treated Cells To Determine The Percentages Of Viable Cells That Was Monitored Using MTT Assay.

Results: The Mean Viability Percentage Of Quercetin Treated Cells (in Relation To Control Cells) Increased As Quercetin Concentration Decreased From 640 MM To 5mM With An IC50 Of 200 MM. Regarding The Cytotoxic Effect Of Quercetin And Related Cell Cycle Profile It Was Noticed That Cell Distribution Showed A Variable Percent Of Arrest At Different Phase Of Cell Division Profile, Where There Was Non Significant Difference Of Arrested Cells Of Quercetin Pre And Post Treatment Compared With Its Value In Non Treated G0-G1 Phase Control Cells(P>0.05) And S Phase As Well. While There Was A Significant Elevated Arrest Of Treated Cells During The G2-M Phase (P<0.05) And The Significant Difference Of Cell Arrest At G2-M Phase Was Type Of Treatment Related . Conclusion: From The Results Of The Current Study, We Found That Quercetin Has Cytotoxic Effect On Squamous Cell Carcinoma, (HEp-2) Cell Line, It Also Induced An Effect On The Cell Cycle Distribution, And Quercetin Has Effect On (HEp-2) Cell Line Resulting In Apoptosis And Necrosis.

Asmaa Yousry Tawfiq, Hoda Abdel Kader Saleh And Salma Belal Eiid,

ABSTRACT


Purpose: To Investigate The Diagnostic Accuracy Of Ultra Low Dose-Cone Beam Computed Tomography Protocol In Detection Of External Root Resorption In Mandibular Teeth.

Materials and Methods: Twenty Extracted Human Mandibular Intact Roots Were Recruited In This In-vitro Diagnostic Study. Simulated Resorptive Defects Of Various Standardized Sizes (0.5mm-0.9mm-1mm) Were Drilled On Each Root Using Inverted Cone Burs With Different Sizes Mounted On Low Speed Hand-piece. Some Sites Were Left Intact On Each Root To Act As Control Sites. The Total Number Of Simulated Defects Was 180 Distributed Randomly On Different Root Surfaces, While A Total Of 60 Sites Were Left Intact. Prepared Roots Were Fitted Into Corresponding Sockets Of A Mandible To Be Scanned By Ultra Low Dose-Cone Beam Computed Tomography Protocol (90 Kvp, 5.6 MA, 4 Seconds) Using A 0.2 Mm Voxel Size And A Field Of View 4x5 Cm .

Results: Ultra Low Dose-Cone Beam Computed Tomography Protocol Had An Overall Sensitivity Of (71%), And Overall Specificity Of (96%). The Diagnostic Accuracy In This In Vitro Study Was (77%). The Positive Predictive Value Recorded Was (98%), While The Negative Predictive Value Was (52%). The Positive Likelihood Ratio Was (18) And The Negative Likelihood Ratio Was (0.3). Conclusion: Ultra Low Dose-Cone Beam Computed Tomography Protocol Could Be Used For Detection Of External Root Resorption With Comparable Diagnostic Accuracy To Standard Protocols But With Significantly Less Radiation Dose.

Asmaa Yousry Tawfiq, Hoda Abdel Kader Saleh And Salma Belal Eiid,

ABSTRACT


Purpose: To Investigate The Diagnostic Accuracy Of Ultra Low Dose-Cone Beam Computed Tomography Protocol In Detection Of External Root Resorption In Mandibular Teeth.

Materials and Methods: Twenty Extracted Human Mandibular Intact Roots Were Recruited In This In-vitro Diagnostic Study. Simulated Resorptive Defects Of Various Standardized Sizes (0.5mm-0.9mm-1mm) Were Drilled On Each Root Using Inverted Cone Burs With Different Sizes Mounted On Low Speed Hand-piece. Some Sites Were Left Intact On Each Root To Act As Control Sites. The Total Number Of Simulated Defects Was 180 Distributed Randomly On Different Root Surfaces, While A Total Of 60 Sites Were Left Intact. Prepared Roots Were Fitted Into Corresponding Sockets Of A Mandible To Be Scanned By Ultra Low Dose-Cone Beam Computed Tomography Protocol (90 Kvp, 5.6 MA, 4 Seconds) Using A 0.2 Mm Voxel Size And A Field Of View 4x5 Cm .

Results: Ultra Low Dose-Cone Beam Computed Tomography Protocol Had An Overall Sensitivity Of (71%), And Overall Specificity Of (96%). The Diagnostic Accuracy In This In Vitro Study Was (77%). The Positive Predictive Value Recorded Was (98%), While The Negative Predictive Value Was (52%). The Positive Likelihood Ratio Was (18) And The Negative Likelihood Ratio Was (0.3). Conclusion: Ultra Low Dose-Cone Beam Computed Tomography Protocol Could Be Used For Detection Of External Root Resorption With Comparable Diagnostic Accuracy To Standard Protocols But With Significantly Less Radiation Dose.

Asmaa A.Desouky, Maged M. Negm And Magdy M.M. Ali .,

ABSTRACT
Objectives The Aim Of This Article Is To Evaluate The Sealability Of Experimental Nanosealers (nano Calcium Hydroxide And Nano Bioactive Glass) And To Compare It With The Commercial Zinc Oxide Eugenol Sealer. Methodology Sixty Single-root Human Mandibular Premolars Were Selected And Instrumented With Protaper Ni-Ti Rotary File And The Final File Size Was Up To # F4/.06. They Were Then Randomly Allocated Into 3 Groups, And All Samples Were Filled With Single Cone Gutta-percha (#40/06) And One Of The Tested Sealers. All Specimens Were Tested By Dye Penetration Test To Evaluate The Sealability Of Newly Introduced Nanosealers. Results Significant Improvement Shown By The Presented Study Suggests That Nano Calcium Hydroxide Sealer Showed Significantly Less Dye Leakage Than Nano Bioactive Glass Sealer And Zinc Oxide Eugenol Sealer. Conclusions The Results Of This Study Showed That The Synthesized Nano-powder Sealers Are Suitable For Use In Root Canal Therapy To Prevent Leakage.

Asmaa Mahmoud Abdeen, Tarik Essawy And Saher Sayed Mohammed,

ABSTRACT
Background: Sofosbuvir (SOF) Was Published In 2013 As A Part Of First-line Treatment For Hepatitis C Virus (HCV) By The�American Association For The Study Of Liver Diseases . SOF Was Recommended For All Genotypes With A Cure Rate Greater Than 90%. Objective: Investigating Sofosbuvir-induced Alterations In The Rat Submandibular Salivary Gland (SMSG) Histologically And Immunohistochemically. Methodology: 80 Adult Rats Weighing About �150 Gm Were Divided Into 2 Groups, Group I (control Group) And Group II (experimental Group) Divided In To 3 Subgroups And Received SOF 40 Mg/kg/day For 1, 2 And 3 Months. All Animals Were Sacrificed, SMSG Were Dissected And Specimens Were Examined Histologically And Immunohistochemically.

Results: Compared To Group I, Group II Subgroup (1) And (2) Showed Acinar And Ductal Vacuolization, Oedema, Discontinuity Of The Epithelial Lining With Retained Coagulum In The Granular Convoluted Tubules (GCTs). These Changes Were Found To Be Exaggerated In Subgroup (3) Accompanied By Acinar And Ductal Shrinkage And Loss Of Gland Compactness. A Statistically Highly Significant Decrease In PCNA Immunoreaction Was Noticed In Experimental Group From Subgroup (1) To Subgroup (3). Conclusion: SOF Had Affected The Structure And Function Of SMSG Through Increased Reactive Oxygen Species (ROS) Levels Leading To Degenerative Changes.

Asmaa Salah El Din Abd El Samea Allam, Sara Ahmed Mahmoudand Sherif Bahgat Eltaweel,

ABSTRACT
Objective: This Study Was Conducted To Assess The Clinical Efficacy Of Mouthwash Containing (Green Tea With Aloe Vera) Versus Chlorhexidine (0.2%) Mouthwash, On Oral Malodor (Halitosis) And Salivary Streptococcus Mutans Counts In A Group Of Egyptian Children. Subjects And Methods: A Randomized Controlled Clinical Trial Was Performed On 54 Healthy Egyptian Children Who Were Randomly Divided Into Two Groups (27 Patients In Each Group), The First Group Rinsed With (Green Tea With Aloe Vera) Mouthwash And The Second Group Rinsed With (chlorhexidine (0.2%)) Mouthwash. The Mouth Odors Of Children Were Assessed By Investigator Nose By Applying The Smell Identification Test (Organoleptic Measurement), At Baseline Zero Min (pre-rinse), 15 Min, 7 Days (post-rinse), Saliva Samples Were Collected From The Child?s Mouth At The Baseline Zero Min (pre-rinse) And After 90 Min (post-rinse) To Determine Streptococcus Mutans Colony Counts.

Results: The Result Showed That Malodor For Both Groups, Baseline Score Of Malodor Had The Highest Mean Value Of Whole Testing Intervals, Followed By 15 Minutes, Then 1 Week, And Also That There Was No Statistically Significant Difference Between The Two Types Of Mouthwashes Regarding Their Effects On Streptococcus Mutans Counts. Conclusion: Both Group (I) Green Tea With Aloe-Vera And Group (II) Chlorhexidine (0.2%) Mouthwash Were Effective In Reducing Oral Malodor And Had Antibacterial Effects.

Asmaa Abou-Bakr, Nevine H. Kheir El Din, Eman Khalil And Radwa R. Hussein,

ABSTRACT
Chronic Kidney Failure (CRF) Is Becoming A Major Public Health Problem Worldwide Particularly In Developed Countries With A Higher Prevalence Of Renal Disease. Hemodialysis Is The Most Widely Used Treatment Of Nephropathy. Both The Disease And The Treatment Can Inflict Respiratory, Endocrine And Immunological Complications, Which Could Influence The Patient?s Oral Status As Well As Alterations In Salivary Flow And Salivary PH. There Are Guidelines For Oral Health Care In Patients With Systemic Diseases; Additionally, A Significant Improvement In The Underlying Systemic Diseases Has Been Reported Following Treatment Of The Associated Oral Lesions

Materials and Methods: 114 Patients Of Each Gender With Age Vary From 30 To 60 Years Diagnosed With End-stage Renal Disease Undergoing Hemodialysis From Six Months Up To Two Years Were Involved In This Study From The Nephrology Department At Benha University. Patients With A History Of Any Serious Sickness As Malignancy Or Who Undergo Kidney Transplants Or Those That Take Medication That Would Cause Oral Manifestations As Steroids And Smokers Were Excluded In Our Study. Oral Examinations Were Done According To The Modified WHO Oral Health Survey 2013 Criteria. Saliva Was Collected Once Pre-stimulation To Measure The Rate Of Flow And PH.

Results: Oral Changes Were Present In All 114 (100%) CRF Patients. Chronic Periodontitis Was The Most Frequently Seen Disease In (81.6%) CRF Patients. Alternative Findings Were Xerostomia, Burning Mouth, Uremic Breath, Petechial Lesions, Pallor, And Abnormal Pigmentation. In Our Study, We Found An Association Between Xerostomia And Salivary Flow Rate. We Also Found That Patients With Lip Pigmentation Showed Statistically Significantly Low Mean Blood Urea Levels. Conclusion: Many Alterations In The Oral And Salivary Parameters Were Found At The CRF Patients. These Patients Need Special Attention Towards Their Dental Treatment, Not Only Because Of The Disease Itself And Its Multiple Oral Manifestations But Also Because Of The Side-effects And Characteristics Of The Treatments They Receive. The Greater Predominance Of Oral Lesions In CRF Patients Imposes Mandatory Oral Screening To Recognize Patients At Risk. The Management Of Such Will Enhance The Overall Well-being Of CRF Patients In Developed Countries.

Moteea Abdulsalam Ahmed Sanad , Basma Gamal Mousa And Khaled Amr ,

ABSTRACT
Temporomandibular Joint TMJ Disorders TMDs Is A Umbrella Term For A Variety Of Conditions Of The Joint And Mastication Muscles. TMJ Arthrocentesis And Intra-articular Injection Are Commonly Known And Used As Minimally Invasive Surgical Treatment Of Tmj Disc Displacement With Reduction. Aim Of The Study: To Compare Between Arthrocentesis Followed By Intra Articular Injection With Plasma Rich In Growth Factors PRGF Versus Arthrocentesis Alone. Patients And Methods: Sixteen Patients Diagnosed With Anterior Disc Displacement (ADD) Were Divided Into; Intervention And Comparative Group. Clinical Outcome Parameters Were Assessed At Baseline And At 6, 12, 18 And 30 Weeks Postoperatively.

Results: Both Groups Showed Significant Improvement Of Pain And Mouth Opening, The Evaluated Parameters Showed Insignificant Differences Between The Two Groups Throughout The Study Intervals With The Exception That The PRGF Group Showed Statistically Significant Pain Reduction And Mouth Opening Improvement In 30 And 6 Weeks Postoperative Respectively (p = 0.01 , 0.03) Conclusion: Both TMJ Arthrocentesis With Intra-articular Injection Of PRGF Or Arthrocentesis Only Was Proved To Reduce Symptoms Of Pain And Limited Mouth Opening And To Maintain Improvements Over Time. PRGF Injection After Arthrocentesis Revealed Some Superiority In Pain Reduction And Mouth Opening Over Arthrocentesis In 30, 6 Weeks Interval Respectively.

Asmaa Salah El Din Abd El Samea Allam , Sara Ahmed Mahmoudand Sherif Bahgat Eltaweel ,

ABSTRACT
Objective: This Study Was Conducted To Assess The Clinical Efficacy Of Mouthwash Containing (Green Tea With Aloe Vera) Versus Chlorhexidine (0.2%) Mouthwash, On Oral Malodor (Halitosis) And Salivary Streptococcus Mutans Counts In A Group Of Egyptian Children. Subjects And Methods: A Randomized Controlled Clinical Trial Was Performed On 54 Healthy Egyptian Children Who Were Randomly Divided Into Two Groups (27 Patients In Each Group), The First Group Rinsed With (Green Tea With Aloe Vera) Mouthwash And The Second Group Rinsed With (chlorhexidine (0.2%)) Mouthwash. The Mouth Odors Of Children Were Assessed By Investigator Nose By Applying The Smell Identification Test (Organoleptic Measurement), At Baseline Zero Min (pre-rinse), 15 Min, 7 Days (post-rinse), Saliva Samples Were Collected From The Child?s Mouth At The Baseline Zero Min (pre-rinse) And After 90 Min (post-rinse) To Determine Streptococcus Mutans Colony Counts.

Results: The Result Showed That Malodor For Both Groups, Baseline Score Of Malodor Had The Highest Mean Value Of Whole Testing Intervals, Followed By 15 Minutes, Then 1 Week, And Also That There Was No Statistically Significant Difference Between The Two Types Of Mouthwashes Regarding Their Effects On Streptococcus Mutans Counts. Conclusion: Both Group (I) Green Tea With Aloe-Vera And Group (II) Chlorhexidine (0.2%) Mouthwash Were Effective In Reducing Oral Malodor And Had Antibacterial Effects.