ABSTRACT
Metformin Is One Of The Most Commonly Used Anti-hyperglycemic Drugs To Treat Type II Diabetes Mellitus, It Was Shown That Metformin Has A Positive Effect On Bone Turn Over Represented In Decreasing Osteoclastic Activity.
The Current Study Aimed To Investigate The Effect Of The Adjunct Use Of Locally Applied 1% Metformin Gel In The Periodontal Pocket, On The Outcome Of Nonsurgical Conventional Treatment Of Moderate Chronic Periodontitis In Smokers.
Methods: Twenty Smoker Patients Diagnosed As Moderate To Severe Chronic Periodontitis Were Selected And Divided Into Two Groups The 1st Is The Study Group That Was Treated By Conventional Treatment (scaling And Root Planing) + Local Delivery Of 1% Metformin Gel (MF) While The 2nd Is The Control Group That Was Treated By Conventional Treatment + Local Application Of Placebo Gel. The Evaluation Of Both Groups Based On Evaluation Of Clinical Parameters (periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Gingival Index (GI) And Plaque Index (PI) In Addition To Biologic And Immunologic Parameters (levels Of Alkaline Phosphatase Enzyme (APE) And Interleukin 1 Beta (IL1?) In Gingival Crevicular Fluid (GCF). The Measurements Recorded At Base Line, After 1 Month, 3 Months And 6 Months Of The Treatment.
Results : PPD Reduction And CAL Gain Was Higher In The 1st Group (MF Group) Than The 2nd Group (placebo Group), Also The GI Enhancement Was Higher In MF Group Than Placebo Group. There Was A Decrease In Levels Of IL1? In Both Groups But At 3 And 6 Months More Reduction Was Seen In MF Group, The Levels Of APE Was Decreased In Both Groups After 1 Month But The Study Group Showed Higher APE Levels At 3 And 6 Months When Compared To 1st Month Levels But Still Less Than The Base Line Level.
Conclusion: 1) According To Clinical Results, The Adjunct Use Of Locally Applied 1%MF Gel To Conventional Non-surgical Treatment Has A Beneficial Positive Effect On The Clinical Outcome Of The Treatment. 2) According To Biologic And Immunologic Results The Adjunct Use Of Locally Applied 1%MF Gel To Conventional Non-surgical Treatment Has An Anti-inflammatory Effect And Bone Formation Effect.