Mohammed Fawzy Habib, Manar Fouda And Shaimaa Ismail Gawdat,

ABSTRACT


Aim: The Study Was Designed To Compare The Anesthetic Efficacy Of 2% Mepivacaine With 1:100000 Epinephrine To That Of 4% Articaine With 1:100000 Epinephrine In Inferior Alveolar Nerve Block Injection For Mandibular Molars With Symptomatic Irreversible Pulpitis. Methods: 66 Patients With Symptomatic Irreversible Pulpitis In Their Mandibular Molars Were Randomly Allocated To Two Groups Receiving IANB Injection Of Either 2% Mepivacaine With 1:100 000 Epinephrine Or 4% Articaine With 1:100 000 Epinephrine. Patients Were Asked To Rate Their Pain Level On A Number Rating Scale (NRS) During Access Cavity Preparation And Root Canal Instrumentation. Patients Who Reported No Or Mild Pain During The Two Procedures Were Considered Successfully Anesthetized, Otherwise The Case Was Considered Anesthetic Failure. Chi Square Test Was Used To Compare The Outcomes Between The Two Groups.

Results: Anesthetic Success Of The Mepivacaine Group Was (33.3%) While That Of Articaine Was 45.5%. The Difference Between The Two Groups Was Not Statistically Significant (p= 0.31). Conclusion: Anesthetic Efficacy Of 2% Mepivacaine Was Similar To That Of 4% Articaine In Inferior Alveolar Nerve Blocks For Anesthetizing Mandibular Molars With Symptomatic Irreversible Pulpitis.

Engy Mostafa Magdy Abdou, Eman Abou Auf And Mohamed Adel Ezzat,

ABSTRACT
This The Study Was Performed To Evaluate The Effect Of Galla Chinensis Extract (GCE) On The Micro Shear Bond Strength Durability Of Self-adhering Flowable Composite Fusio�Liquid Dentin) To Dentin. M&M: Fifty Two Extracted Human Molars Were Selected, Enamel Surfaces Were Flattened. The Teeth Were Randomly Divided Into Two Main Groups (A) (n=26). (A0) Was For Self-adhering Flowable Composite Without GCE (control) And (A1) Was For Self-adhering Flowable Composite With GCE. Each Main Group Was Divided Into Two Subgroups (T) According To Time Of Testing; (T1) After 24 Hours, (T2) After Three Months (n=13). All Specimens Were Stored In Artificial Saliva. Micro Shear Bond Strength Test Was Conducted Immediately After 24 Hours And After Three Months Using Universal Testing Machine. The Results Showed That The Highest Micro Shear Bond Strength Was For GCE Group After 24 Hours Storage And The Lowest Mean Micro Shear Bond Strength For The Control Group After Three Months Storage. There Was A Statistically Significant Difference (p?0.001) Between The GCE Groups And The Control Groups On The Mean Micro Shear Bond Strength Of Fusio� Liquid Dentin. Conclusion: GCE As A Natural Cross Linking Agent Could Be Of Positive Value On The Micro Shear Bond Strength Of Self-adhering Flowable Composite And Time Has No Significance On The Micro Shear Bond Strength.

Ahmed Zakaria Al-Adl, Amal Fathy Kaddah And Ahmed Emad Fayyad,

ABSTRACT
Two Implant Retained Mandibular Overdenture Is A Simple Solution In Rehabilitation Of Edentulous Patients. Equator Attachment Offers A Lower Profile Than The Self-aligning Attachment But There Is No Enough Researches That Compare Between Them.

Aim: Clinically Compare Between Both Groups Regarding Oral Health Related Quality Of Life And Overdenture Retention In Edentulous Patients Restored With Implant Overdenture.

Materials and Methods: Complete Denture Fabricated, Then Two Implants Placed At The Canine Region. Equator Attachments Connected To Group I And Self-aligning Attachments Connected To Each Group II. The Arabic Version Of The Oral Health Impact Profile For The Edentulous Patients Was Used Specifically To Evaluate The Impact Of Implant Prosthesis On The Patient�s Quality Of Life. Overdenture Retention Was Measured According To The Method Reported By (Jose F. Ma�es Et Al., 2011) Using A Spring Scale To Measure Retention Strength (in Newton).

Results: Regarding Oral Health Related Quality Of Life, There Was Statistically Significant Improvement From Time Of Insertion To 3 Months In Both Groups. There Was No Statistically Significant Difference Between Both Groups At Insertion Time And After 3 Months. Regarding Overdenture Retention, There Was Decrease Of Retention From Time Of Insertion To 3 Months Follow-up Periods With Statistically Significant Difference In Both Groups Of Study. Equator Group Showed Statistically Significant More Retention Force Compared To That Of Locator Group At Time Of Insertion, However, There Was No Statistically Significant Difference Between Two Groups At 3 Months Follow-up Period. Conclusion: Oral Health Related Quality Of Life Was Not Affected By The Attachment Type Or The Attachment Profile And It Usually Enhances With Time With Different Types Of Attachment. Regarding Overdenture Retention, Equator Attachment Presented Higher Retention Values Than Self-aligning Attachment At The Beginning Of The Study But It Showed Faster Retention Loss Than Self-aligning Attachment With Time.

Omnia Ahmed Badawi, Amal Hassan Abdel-Rahman And Hend Mohammed Wagih,

ABSTRACT
Background: Some Odontogenic Tumors Such As Ameloblastoma (AB), Ameloblastic Carcinoma (ABC) And Keratocystic Odontogenic Tumor (KOT) Have Aggressive Behavior With High Recurrence Rate. Cancer Stem Cells (CSCs) Are Small Subpopulation Groups Of Cells That Are Hypothesized To Be Responsible For Tumors� Aggressiveness And Recurrence. ABCG2 And CD44 Are CSC Markers, So The Aim Of This Study Is To Detect Their Expression In These Lesions Which Will Confirm The CSCs Origin Of Such Lesions.

Materials and Methods: 37 Specimens (15 AB, 10 ABC, 10 KOT And 2 Tooth Follicles Of Permanent Teeth) Were Collected; ABCG2 And CD44 Cytoplasmic, Membranous As Well As Nuclear Immunohistochemical Expressions Were Evaluated. The Area Percent Was Measured For The Positive Immunoexpression Of The Markers.

Results: As Regards ABCG2, A Highly Significant Difference Was Found Between Tooth Follicle, AB, ABC And KOT With The Highest Expression Was Observed In Tooth Follicle. In Contrast To CD44 Where No Statistical Significance Was Found Between AB, ABC And KOT With The Highest Expression Was Detected In AB. Conclusion: CD44 Had Diffuse Positive Immunoexpression In All Lesions In Contrast To ABCG2 That Was Mainly Detected In The Tooth Follicles With Frequent Focal Immunoexpression In The Tumors. So CD44 Was Considered To Be More Reliable Marker For CSCs Than ABCG2, Thus Making Such Tumors Potential Targets For Anti-CD44 Therapies.

Mohamed Omar Ismail , Ahmed A. Khalil And Mohamed Abdelmoniem. Ebrahem,

ABSTRACT
Objective: The Aim Of This Study Was To Evaluate And Compare The Efficacy Of PRF Combined With Biodentine And Biodentine Alone In The Treatment Of Class II Furcation Defects. Methods:�fourteen Patients With 28 Grade II Furcation Defect Were Treated With Either Open Flap Debridement And Biodentine Occlude Furcation Entrance (Group 1), Open Flap Debridement With PRF And Biodentine Occlude Furcation Entrance (Group 2) Plaque Index, Gingival Index, Probing Pocket Depth (PD), Clinical Attachment Level And Furcation Probing Were Recorded At Baseline And 3,6 Months Postoperatively. .

Results: The Results Of This Study Showed Significant Pocket Depth Reduction In Both Groups Throughout The Different Periods Of The Study. Statistical Analysis Showed Significant Decrease In Mean CAL From Baseline To 6 Months In Both Groups. Statistical Analysis Showed Significant Decrease In Mean HPD After 3 Months And After 6 Months In Both Groups. Regarding The Radiographic Parameters, Bone Density Increased From Baseline To 6 Months In Both Groups.

Conclusions:�Furcation Defect Treatment With Autologous PRF Combined With Biodentine And Biodentine Alone Results In Significant Reduction In Pocket Depth, Gain In Clinical Attachment, Gain In Vertical And Horizontal Clinical Attachment Level And Increase In Bone Density. Although PRF Combined With Biodentine Group Show More Improvement Regarding Both Clinical And Radiographic Parameters, There Was No Significant Difference

Mohamed Hanafy Tawfik; Manal Mohamed Hosny; Enji Ahmed Mahmoud And Olfat Gamil Shaker,

ABSTRACT

Objectives: The Aim Of This Study Was To Evaluate The Effect Of Systemic Administration Of Green Tea In Conjunction With Scaling And Root Planing Versus Scaling And Root Planing Alone On The GCF Total Antioxidative Capacity And Clinical Parameters In Patients With Generalized Moderate Chronic Periodontitis. Methods: Twenty Eight Patients Participated In This Study And Randomly Allocated Into Two Groups Group I (Test Group): Fourteen Patients Received Scaling And Root Planing Supplemented With Green Tea Tablets (300mg) To Be Taken Once Daily For 3 Months. Group II (Control Group): Fourteen Patients Received Scaling And Root Planing Supplemented With Placebo Tablets. The Following Clinical Parameters (Plaque Index PI, Gingival Index GI , Probing Pocket Depth PD And Clinical Attachment Level CAL) As Well As The Level Of Total Antioxidant Capacity (TAC) In The GCF Were Recorded And Measured At Baseline And 3 Months Post-treatment.

Results: Both Groups Showed Statistically Significant Improvement In All Clinical Parameters With No Difference Between Them. Test Group Showed More Statistically Significant Increase In TAC Than Do The Control Group. Conclusion: Green Tea Has A Therapeutic Effect As Anti-oxidant In The Treatment Of Patients With Chronic Periodontitis

Arwa Abu El-Magd , Tarik Essawy And Saher Sayed Mohammed,

ABSTRACT


Introduction: Botulinum Toxin-A (BTX-A) Is One Of The Most Poisonous Naturally Occurring Substances. It Blocks The Release Of Acetylcholine, The Principal Neurotransmitter At The Neuromuscular Junction, Causing Muscle Paralysis. This Toxin Is Licensed As A Drug For Medical Use Such As Being Used Effectively As Cosmetic Agent For Treatment Of Wrinkles On The Face. Aim Of The Work: This Study Was Carried To Evaluate The Effect Of Botulinum Toxin-A Injection On Rabbit Orbicularis Oris Muscle Histologically And Immunohistochemically.

Materials and Methods: Twenty Adult Healthy Male New Zealand White (NZW) Rabbits Weighing 2-2.5 Kg Were Used In This Study. The Animals Were Divided Into Two Main Groups (control And Experimental Groups). The Control Group (Group I) Consisted Of 5 Rabbits. Upper Lip Of Rabbits In Group I Was Injected By 0.05 Ml Saline. The Experimental Group (group II); Consisted Of 15 Rabbits And Divided Into 3 Subgroups (5 Rabbits In Each). Upper Lip Of Rabbits In Each Subgroup Was Injected By 2 U Of Botox. Rabbits In Group I & II Were Sacrificed After One, Two And Four Weeks. Animals Were Killed And The Upper Lip Of All Rabbits Was Dissected And Processed For Paraffin Sectioning And Stained With Hematoxylin And Eosin For Histological Examination And Caspase-3 For Immunohistochemical Examination.

Results: Histological Examination Of Subgroup 1&2 Showed Degenerated, Fragmented And Atrophied Muscle Fibers. In Subgroup 3, Perimysial Fibrosis And Fat Cell Accumulation Were Detected. Immunohistochemical Results Showed Increase In The Cytoplasmic Immunopositivity Of Caspase -3 In The Muscle Fibers From Experimental Subgroup 1 To Experimental Subgroup 3. Conclusion: Injection Of BTX-A Into Orbicularis Oris Muscle Revealed Deleterious And Damaging Effects On Histological Basis.

Eman Khodary Allam, Eman Sobhy El-Shamy And Omneya Mohamed Wahba,

ABSTRACT
Background: Oral Squamous Cell Carcinoma (SCC) Is A Characteristic Aggressive Tumor Representing A Significant Public Health Threat All Over The World. It Has Been Found In Several Body Malignancies That Cancer Stem Cells (CSCs) Are Small Subpopulation Of Cells Within The Tumor That Exhibit Self-renewing Ability And Are Responsible For Tumor Main�tenance, Growth And Metastasis.
Objectives: The Aim Of This Work Was To Investigate The Immunolocalization Of Cancer Stem Cells Markers; CD44 And ALDH1 In SCC And To Correlate The Expression Of These Markers In SCC Cases With Nodal Metastasis.

Materials and Methods: A Total Of 49 Specimens Of Oral SCC Were Divided Into 24 Cases With Nodal Metastasis And 25 Cases Without Nodal Metastasis For Evaluation Of Metastasis. Tissue Specimens Were Stained Immunohistochemically With Antibodies Against CD44 And ALDH1.

Results: CD44 And ALDH1 Expressions Increased In Poorly Differentiated SCCs. CD44 Expression Was Found To Be Statistically Highly Significant Relating To Histopathologic Grades Of Oral SCC. There Was A Non-significant Relation Between ALDH1 And Histopathologic Grades Of SCC. It Was Also Found That CD44 & ALDH1 Expressions Were Significantly Related To Lymph Node Status Of Primary SCC Cases.

Conclusions: The Results Of The Present Study Have Indicated That CD44 And ALDH1 Are Potential Markers Of CSCs In SCC. CSCs Positively Stained Cell Count Increased With Increasing The Grade Of SCC. Increased Expressions Of CD44 And ALDH1 In Primary SCCs Can Be Considered As A Useful Indicator Of The Metastatic Potential To Their Regional Lymph Nodes.

Dina Ahmed AbdEllatif , Lamiaa Sayed Kheirallah And Maha Ahmed Taymour,

ABSTRACT
Conservation Of The Tooth Substance Connected With Aesthetic Treatment Modalities For Teeth Led To Rise In The Placement Of Indirect Restorations; Inlay, Onlay, Endo-crown, Veneer, Partial Coverage And Full Coverage Restorations In The Recent Years. The Aim Of This Study Was To Evaluate The Shear Bond Strength Of Vita Enamic Discs Bonded To Enamel And Dentin Using Bifix QM Resin Cement Versus Rely X Ultimate Resin Cement.

Materials and Methods: Twenty Eight Human Premolar Teeth Were Selected Then Divided Into Two Main Groups According To The Cement Used Then Further Subdivided Into Two Subgroups According To The Dental Substrate Either Enamel Or Dentin (n=7). Ceramic Discs Of 2mm Height And 4mm Diameter Were Cemented By Relay X Ultimate As A Control And Bifix QM As An Intervention. All Specimens Were Stored In Distilled Water For 24hr At 37?. The Specimens Were Loaded Until Fracture In A Shear Test At A Crosshead Speed Of 0.5mm/min In A Universal Testing Machine After Thermocycling.

Results: Relay X Cement Showed Significant Higher Shear Bond Strength In Enamel Substrate. Bifix QM Cement Showed Non Significant Higher Bond Strength In Dentin Substrate.

Conclusions: Rely X Ultimate Becomes The Cement Of Choice In The Cementation Of Conservative Restoration As Veneers. Both Cements Can Be Used For Bonding Vita Enamic Restorations With More Preferences To Bifix QM Cement When Most Of The Preparation In Dentin.

Aziz F. Al-Sayed, Ghali R. Abdel Malek And Salem. Z. Amin,

ABSTRACT
Aim Of The Study: Artificial Sweeteners Such As�aspartame (APM) Are Widely Consumed Nowadays, Yet Their Long-term Health Impact Is Uncertain. The Present Work Aimed To Investigate The Effect Of Long Term Administration Of High Dose Of APM (80mg/kg.b.w) On The Structural Features Of Von Ebner?s Salivary Glands, Circumvallate Papillae And Taste Buds.

Materials and Methods: Twenty-two Male Adult Albino Laboratory Rats With Weight Range From 200 To 250 G Were Utilized In The Present Study. The Animals Were Divided Into 2 Groups; Group I: Consisted Of Eleven Rats And They Were Considered As Control Group. Group II: Consisted Of Eleven Rats And They Were Given APM (80 Mg/kg.b.w) Dissolved In Distilled Water Orally And Daily By Means Of Gastric Tube. The Rats Were Sacrificed At The End Of The Sixth Months Under Chloral Hydrate Anesthesia. The Tongue Was Subsequently Dissected And Prepared For Histological Examination Using H&E Stain, Immunohistochemical Staining Using PCNA Antibody And Finally Histomorphometric And Statistical Analysis Were Performed.

Results: The Histopathological Results After Long Term Administration Of APM Showed Partially Obliterated Trough Of Circumvallate Papilla With Hyperkeratinization. Abnormal Morphology Of The Excretory Duct Was Observed, The Ductal Lining Showed Squamous Hyperplasia With Collapsed Lumen. Severe Degeneration In The Von Ebner?s Salivary Glands With Loss Of The Normal Architecture Of The Serours Acini Were Observed With Appearance Of Signs Of Premalignancy. Immunohistochemical Results Showed Very High Rate Of Proliferative Activity After Long Term Administration Of APM In Comparison To Control Group. Conclusion: Aspartame Is Considered As A Very Harmful Premalignant Drug On Long Term Administration. So, The Public Should Be Alerted About The Adverse Effects Of Aspartame.