Abdalla Ashraf Nadiem, Amr Helmy El Bolok And Sherif Farouk El-Gayar .,

ABSTRACT
Background: The World Health Organization (WHO) Reported Oral Cancer As Having One Of The Highest Mortality Ratios Amongst All Malignancies. Sinapic Acid Is One Of The Phenolic Compounds Which Considered A Group Of Key Plant Metabolites Which Can Induce Apoptosis In Laryngeal Carcinoma Cells. Aim Of This Study: The Aim Of The Study Is To Investigate The Influence Of Sinapic Acid Versus Nano Sinapic Acid On Induction Of Apoptosis In Human Laryngeal Carcinoma Cell Line Using PCR.

Materials & Methods: Treatment Of Cell Line (HEp-2) By Different Concentrations Of Sinapic Acid And Nano-sinapic Acid Was Done To Assess The Viability Of The Treated Cells To Determine The Percentages Of Viable Cells That Was Monitored Using MTT Assay And To Asses Ahe Apoptotic Effect Of These Drugs Using Real Time PCR.

Results: The Mean Viability Percentage Of Sinapic Acid And Nano-sinapic Acid Treated Cells (in Relation To Control Cells) Increased As Sinapic And Nano-sinapic Acid Concentration Decreased From 1000 MM To 4.88mM In Which The IC50 Of Sinapic Acid Is 565.42 MM.and 644.15 For Nano-sinapic Acid. There Is Increase In Fold Change In Apoptotic Genes (caspase And P53) Which Indicate The Apoptotic Activity Of Sinapic And Nano-sinapic Acid. It Was Concluded That Sinapic Acid Induce Apoptosis And Change Cancer Cell Morphology Due To Their Pro-apoptotic Activity.

Islam Refaat Ali Ahmed And Manal Rafei Hassan,

ABSTRACT

Objectives: The Aim Of The Study Is To Assess The Microleakage Of Laminate Veneer Constructed Of Two Ceramic Materials.

Materials and Methods: Forty Recently Extracted Caries Free Human Upper Central Incisors Were Collected, Cleaned Then Disinfected. The Teeth Were Divided Randomly Regarding The Material (Hybrid Ceramic And High Translucent Zirconia) Into 2 Groups N=20. The Teeth Were Prepared In A Feather Edge Design Then Their Laminate Veneers Were Designed And Milled By CAD CAM System. The Porcelain Laminate Veneers Were Cemented To The Prepared Teeth, Thermocycled, Stored In Fuchsine Dye For 24 H And Then Sectioned Labiopalatally. The Samples Were Investigated Incisally And Cervically For Dye Penetration By The Stereomicroscope. The Obtained Data Were Then Statistically Analyzed Using The 2 Way Anova And Independent Student T Test.

Results: Using The Independent Samples T Test, It Was Found That There Was Significant Microleakage Difference Between The Two Material Types. Vita Enamic Showed Low Microleakage Than Zirconia In Both Incisal And Cervical Margins. Conclusion: There Was Significant Relation Between The Microleakage And The Material Type. Vita Enamic Has Better Marginal Sealing Than Zirconia.

Hadeer Abd Elhady Abd Elhameed, Nadia Ahmed Abbas And Nagla M.H Nassouhy .,

ABSTRACT
Randomized Clinical Trial Was Carried Out To Compare Between Biting Force Of Mandibular Complete Denture Constructed From Two Different Materials; Metal Reinforced Polyamide And Conventional PMMA. Twenty Four Completely Edentulous Patients. The Patients Were Divided Into Two Equal Groups, Group I Received Conventional Maxillary And Mandibular Heat Cured PPMA And Group II Received Conventional Heat Cured Maxillary Denture And Metal Reinforced Polyamide Mandibular Denture. Patients Of Both Groups Were Evaluated By Biting Force Measurements At The Time Of Prosthesis Insertion As Well As Three And Four Weeks Later By Load Star Sensor. The Results; There Was No Statistical Significant Difference In Biting Force Between Conventional Heat Cured PMMA And Metal Reinforced Polyamide Mandibular Denture During All Follow Up Periods.

Youssef Y. Ashour, Samir I. Bakry, Sanaa H. Abd Elkadr And Fayzal Elabbasy .,

ABSTRACT
BACKGROUND: Veneered All-ceramic Restorations Are Associated With A High Incidence Of Chipping And Veneer Delamination From The Inner Core. Monolithic All-ceramic Crowns Facilitate The Fabrication Process And Minimize Residual Stresses Between Core And Veneer. A New Material, Zirconia-reinforced Lithium Silicate (ZRL), Celtra Duo Was Recently Introduced For Fabrication Of Monolithic Anterior Crowns To Overcome The Aesthetic Drawbacks Of Traditional Zirconia And Also To Improve The Strength Of The Lithium Disilicate. Aim Of The Study: To Evaluate The Biaxial?flexural?strength Of CAD/CAM: Zirconia Reinforced Lithium Di Silicat And To Compare It With Lithium Silicate Glass-ceramic Crowns.

Materials and Methods: Thirty Monolithic Ceramic Specimens Will Be Fabricated And Divided Into THREE Main Groups; Group I: CAD/CAM ZLS Celtra Duo Milled And Polished, Group II CAD /CAM ZLS Celtra Duo Milled And Glazed & Group III: CAD/CAM Lithium Silicate Glass-ceramic (e.max CAD). For Evaluation Of The Biaxial?flexural?strength 30 Ceramic Disc Specimens (10mm Diameter ? 1.5mm Thickness) Ten Specimens From Each Material(N=10), Subgroups Ia, IIa, IIIa Will Be Fabricated According To The Manufacturers? Instructions And Thermocycled To Simulate One Year Clinical Service. Biaxial Flexural Strength Will Be Measured For The Same Specimens (Ia, IIa, IIIa). For Evolution Of Marginal Fit 30 Ceramic Crowns Will Be Fabricated, Ten Crowns From Each Material (N=10), Subgroups Ia, IIa, IIIa.

Results: Will Be Tabulated And Statistically Analyzed.

Hadeel Ahmad Kotat, Louloua Mohamed Fathy And Marwa Mokbel ElShafei,

ABSTRACT
Background: Oridonin Extract Has A Wide Range Of Pharmacological And Therapeutic Aspects Including Reactive Oxygen Species Scavenging And Anti-inflammatory Effects. Moreover, The Effect Of Oridonin Extract Has Been Studied In Many Cancers Such As Hepatic And Breast Cancer And Showed Cytotoxic And Anti-proliferative Effects Against Cancer Cell Lines.

Aim: To Assess And Compare The Anti-proliferative And Apoptotic Effect Of Oridonin, Cetuximab And Their Combination In Cultured Oral Squamous Cell Carcinoma Cell Line (tongue).

Materials and Methods: Oral Tongue Squamous Cell Carcinoma Cell Line Was Divided Into 4 Groups: Control Group, Group Treated With Oridonin Extract, Group Treated With Cetuximab And Group Treated With A Combination Of Both. Cell Viability Was Measured Using Microculture Tetrazolium Assay, Apoptotic Activity Was Evaluated Using Polymerase Chain Reaction And Epidermal Growth Factor Receptor Levels Was Measured Using Enzyme Linked Immunosorbent Assay.

Results: Oridonin Extract Succeeded To Decrease The Percentage Of Viable And Proliferating Cells. Furthermore, It Increased The Levels Of Caspase-3 And Decreased Epidermal Growth Factor Receptor Expression. The Highest Level Of Expression Of Caspase -3 Was Found In The Combination Group With A 20.75 Fold Change. Correspondingly, Epidermal Growth Factor Receptor Expression Was The Least In The Combination Group, With An IC50 Of 9.96. Conclusion: Oridonin Extract Has A Potential Cytotoxic Effect On Oral Squamous Cell Carcinoma Cell Line And Exerts This Action Through Induction Of Apoptosis And Its Action Is Comparable To Cetuximab.

Hussam Ashraf Mahmoud Okba Omniya Mohamed Abdel Aziz, And Emad Saeed Helmy .,

ABSTRACT
The Aim Of This Review Is To Discuss The Maxillary Stability In Cleft Lip And Palate Patients Suffering Of Maxillary Hypoplasia Using Conventional Orthognathic Surgery And Distraction Osteogenesis. Various Reports Have Noted A Relapse Or Partial Regression Towards The Pre-operative State In CO.1,2 Some Studies Reported Improved Results With The Use Of Distraction Osteogenesis Over The CO And Have Reported A Decrease In The Skeletal Relapse3,4 , While Other Studies Did Not Report Any Significant Difference In Skeletal Relapse Of CL/P When Using CO Versus Distraction Osteogenesis.5

Hebatallah Mostafa, Saied Mohamed Abd El Aziz And Abeer Saba .,

ABSTRACT
It Is Widely Known That The Prepared Canals Can Never Be Sterile Before Obturation, No Matter How Potent The Antibacterial Irrigants Or Intracanal Medications Are. There Are Currently Two Means To Reduce Bacterial Persistence And Reinfection In The Canals. We Can Either Fill The Canals With Antibacterial Agents In Many Visits Or Immediately Obturate The Canals, To Decrease The Space For Bacterial Colonization, In A Single-visit Approach. The Goal Of The Present Study Was To Compare The Intensity Of Postoperative Pain Following One-visit Versus Two-visit Root Canal For Instrumentation Of Root Canals. Methods: Fifty Patients Who Fulilled Specific Inclusion Criteria Were Assigned To Two Groups According To The Root Canal Instrumentation Technique Used, One-visit Versus Two-visit Root Canal Treatment Was Carried Out And The Severity Of Postoperative Pain Was Assessed By Visual Analogue Scale (VAS) Scores After The Session Until Complete Pain Relief Was Achieved.

Results: Mean Of VAS Scores Between The Two Groups And Within The Same Group At Different Follow Up Periods (6, 12, 24 And 48 Hours) Showed No Statistically Significant Difference.

Ali Morsy Ali, Raafat Hassan Anwar Riad, Mohamed Khalifa And Khairy Elmorsy .,

ABSTRACT

Objectives: To Radiographically Assess The Crestal Bone Level Change Around Implant Located Posteriorly After Immediate Loading Versus Delayed One. Methods: The Study Was Conducted On 20 Patients (10 Males And 10 Females), With The Mean Age Of 26.5 Years (range, 22 Y To 48 Y), Selected From The Dental Outpatient Clinic Of The Military Hospital Of Kobri Elkoba Seeking Replacement Of Missed Lower First Molar. The 20 Patients Were Divided Into Two Equal Groups 10 Patients Each; Study Group And Control Group. Results There Was No Statistically Significant Difference Between The Two Groups (P-value = 0.444). As Regards The Overall Amount Of Bone Loss (mean Of The Two Surfaces); The Recorded Mean And Standard Deviation Values Of Amounts Of Bone Loss Were 0.50 � 0.09 Mm And 0.53 � 0.07 Mm For Immediate And Delayed Loading Groups, Respectively. There Was No Statistically Significant Difference Between The Two Groups (P-value = 0.545). Conclusions Immediate Loading For Posterior Mandibular Teeth Is A Viable Technique And Gives A Predictable Results

Sara Khaled Selim, Mai Mahmoud Yousry, Ahmed Abd El-Fattah Al-Zohairyand Mohamed Refaat El-Bialy .,

ABSTRACT
This Study Was Performed To Evaluate Microhardness And Fracture Resistance Of Sonic-fill Versus Bulk-fill Resin Composite Restorations. Materials And Methods A Total Number Of 80 Standardized MOD Cavities Were Prepared In 80 Maxillary Premolars. The Teeth Were Randomly Divided Into Two Equal Groups, Of 40 Teeth Each, According To The Material; Either SonicFill Resin Or X-tra Fil Resin Composite. Each Group Was Divided Into Two Equal Subgroups, Of 20 Teeth Each, According To Sonic Vibration Applied; Either Application Of Resin Composite Using Sonic Vibration Or Without Sonic Vibration. Each Subgroup Was Divided Into 2 Classes, Of 10 Teeth Each, According To The Aging Duration; Either After 24 Hours Or 12 Months In Artificial Saliva At 37?C. Five Teeth From Each Class Were Used For Microhardness Testing And The Other Five Were Assigned For Fracture Resistance Testing. An Extra Group Of Five Unprepared Teeth Was Used As Sound Control For Fracture Resistance Test. Vickers Microhardness Test Was Performed With Load Of 300 Gm For 10 Seconds, Then HV Hardness Scale Was Used At 3 Depths. For Fracture Resistance, Teeth Were Subjected To Compressive Axial Loading Until Fracture Occurred.

Results: Regarding Microhardness, The Results Showed That X-tra Fil Had A Higher Mean Microhardness Number Than Sonicfill, Also It Showed That Aging Increased The Mean Microhardness On All Specimens. On The Other Hand, Vibration Had No Effect On Mean Microhardness. Moreover, Neither Of The Three Variables Implicated In This Study Had Any Significant Effect On The Fracture Resistance Within The Restored Groups. Nevertheless, Sonicfill Showed No Significant Difference When Compared With Control Group When Applied Without Vibration.

Conclusions: Regarding The Materials, X-tra Fil Showed Higher Microhardness Value Than SonicFill. On The Contrary, SonicFill Was Advantageous Over X-tra Fil Regarding Fracture Resistance, When Applied Without Vibration. However, With Vibration, Both Materials Behaved Similarly. Sonic Vibration Did Not Influence The Microhardness Nor The Fracture Resistance Of Both Materials.

Nada Mohamed Sherif , Hala Kamal Abdel Gaber And Ahmed Elsayed Hamed Amr,

ABSTRACT


Aim: 1ry Objective: To Compare Two Different Approaches Applied In Conjunction With Immediately Placed Dental Implant Regarding The Enhancement Of The Soft Tissue Profile Around The Implant. 1st Approach Is The Placement Of The Particulate Bone Graft In A Surgically Created Sub-periosteal Pouch Adjoining The Buccal Plate Around The Implant, While The 2nd Approach Is The Placement Of Connective Tissue Graft In Surgically Created Sub-periosteal Pouch Adjoining The Buccal Plate Around The Implant. 2ry Objective: To Compare The Formerly Described Approaches Regarding The Effect On The Labial Alveolar Bone Around The Immediate Dental Implant. Subjects And Methods: Sixteen Extraction Sockets In 16 Patients Were Included In This Study. Eight Of Them (test Group), Were Treated With Placing A Bone Graft Overlying The Buccal Bone Plate In A Surgically Created Pouch, And Eight Of Them (control Group) Were Treated With Placing A Subepithelial Connective Tissue Graft Overlying The Buccal Plate In A Surgically Created Pouch. Result: 1- Keratinized Gingival Thickness, In Group (1), The Mean Value Increased From Baseline To 9 Months. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.048). In Group (2), The Mean Value Increased From Baseline To 9 Months. Paired T Test Revealed That The Difference Was Extremely Statistically Significant (p=0.00). Regarding The Percent Of Change In Group (1) In Comparison To A Percent Of Change In Group (2), Mann Whitney U Test Revealed That The Difference Was Not Statistically Significant (p=0.44). 2- Keratinized Gingiva Width, In Group (1), The Mean Value Increased At 9 Months In Comparison To Baseline. Paired T Test Revealed That The Difference Was Not Statistically Significant (p=0.064). In Group (2), The Mean Value Decreased At 9 Months In Comparison To Baseline. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.02). 3- CBCT (measuring The Bucco-lingual Ridge Width): In Group (1), The Mean Value Decreased After Treatment. Paired T Test Revealed That The Difference Was Not Statistically Significant (p=0.268). In Group (2), The Mean Value Increased After Treatment. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.013). And Regarding The Percent Of Change After Treatment, A Decrease Was Noted In Group (1), While An Increase Was Noted In Group (2). Mann Whitney U Test, Revealed That The Difference Was Statistically Significant (p=0.02). 4- Marginal Bone Level: Regarding The Percent Of Change Between Two Groups From Base-line To 9 Months, A Mean Percent Of Change Increase Was Recorded In Group (1), While A Mean Percent Of Change Decrease Was Noted In Group (2). Mann Whitney U Test, Revealed That The Difference Was Statistically Significant (p=0.01). Conclusion: Particulate Xenograft Used In Labial Sub-periosteal Pouch Around Immediate Implant Enhances The Gingival Biotype And Keratinized Gingival Width Thus Can Optimize The Soft Tissue Profile And Final Esthetics. Moreover, It Helps In Minimizing Crestal Bone Loss But Has No Remarkable Effect On Ridge Bucco-lingual Bone Changes.