Hadeel Ahmad Kotat, Louloua Mohamed Fathy And Marwa Mokbel ElShafei,

ABSTRACT
Background: Oridonin Extract Has A Wide Range Of Pharmacological And Therapeutic Aspects Including Reactive Oxygen Species Scavenging And Anti-inflammatory Effects. Moreover, The Effect Of Oridonin Extract Has Been Studied In Many Cancers Such As Hepatic And Breast Cancer And Showed Cytotoxic And Anti-proliferative Effects Against Cancer Cell Lines.

Aim: To Assess And Compare The Anti-proliferative And Apoptotic Effect Of Oridonin, Cetuximab And Their Combination In Cultured Oral Squamous Cell Carcinoma Cell Line (tongue).

Materials and Methods: Oral Tongue Squamous Cell Carcinoma Cell Line Was Divided Into 4 Groups: Control Group, Group Treated With Oridonin Extract, Group Treated With Cetuximab And Group Treated With A Combination Of Both. Cell Viability Was Measured Using Microculture Tetrazolium Assay, Apoptotic Activity Was Evaluated Using Polymerase Chain Reaction And Epidermal Growth Factor Receptor Levels Was Measured Using Enzyme Linked Immunosorbent Assay.

Results: Oridonin Extract Succeeded To Decrease The Percentage Of Viable And Proliferating Cells. Furthermore, It Increased The Levels Of Caspase-3 And Decreased Epidermal Growth Factor Receptor Expression. The Highest Level Of Expression Of Caspase -3 Was Found In The Combination Group With A 20.75 Fold Change. Correspondingly, Epidermal Growth Factor Receptor Expression Was The Least In The Combination Group, With An IC50 Of 9.96. Conclusion: Oridonin Extract Has A Potential Cytotoxic Effect On Oral Squamous Cell Carcinoma Cell Line And Exerts This Action Through Induction Of Apoptosis And Its Action Is Comparable To Cetuximab.

Hussam Ashraf Mahmoud Okba Omniya Mohamed Abdel Aziz, And Emad Saeed Helmy ,

ABSTRACT
The Aim Of This Review Is To Discuss The Maxillary Stability In Cleft Lip And Palate Patients Suffering Of Maxillary Hypoplasia Using Conventional Orthognathic Surgery And Distraction Osteogenesis. Various Reports Have Noted A Relapse Or Partial Regression Towards The Pre-operative State In CO.1,2 Some Studies Reported Improved Results With The Use Of Distraction Osteogenesis Over The CO And Have Reported A Decrease In The Skeletal Relapse3,4 , While Other Studies Did Not Report Any Significant Difference In Skeletal Relapse Of CL/P When Using CO Versus Distraction Osteogenesis.

Hebatallah Mostafa, Saied Mohamed Abd El Aziz And Abeer Saba,

ABSTRACT
It Is Widely Known That The Prepared Canals Can Never Be Sterile Before Obturation, No Matter How Potent The Antibacterial Irrigants Or Intracanal Medications Are. There Are Currently Two Means To Reduce Bacterial Persistence And Reinfection In The Canals. We Can Either Fill The Canals With Antibacterial Agents In Many Visits Or Immediately Obturate The Canals, To Decrease The Space For Bacterial Colonization, In A Single-visit Approach. The Goal Of The Present Study Was To Compare The Intensity Of Postoperative Pain Following One-visit Versus Two-visit Root Canal For Instrumentation Of Root Canals. Methods: Fifty Patients Who Fulilled Specific Inclusion Criteria Were Assigned To Two Groups According To The Root Canal Instrumentation Technique Used, One-visit Versus Two-visit Root Canal Treatment Was Carried Out And The Severity Of Postoperative Pain Was Assessed By Visual Analogue Scale (VAS) Scores After The Session Until Complete Pain Relief Was Achieved.

Results: Mean Of VAS Scores Between The Two Groups And Within The Same Group At Different Follow Up Periods (6, 12, 24 And 48 Hours) Showed No Statistically Significant Difference.

Ali Morsy Ali, Raafat Hassan Anwar Riad, Mohamed Khalifa And Khairy Elmorsy,

ABSTRACT

Objectives: To Radiographically Assess The Crestal Bone Level Change Around Implant Located Posteriorly After Immediate Loading Versus Delayed One. Methods: The Study Was Conducted On 20 Patients (10 Males And 10 Females), With The Mean Age Of 26.5 Years (range, 22 Y To 48 Y), Selected From The Dental Outpatient Clinic Of The Military Hospital Of Kobri Elkoba Seeking Replacement Of Missed Lower First Molar. The 20 Patients Were Divided Into Two Equal Groups 10 Patients Each; Study Group And Control Group. Results There Was No Statistically Significant Difference Between The Two Groups (P-value = 0.444). As Regards The Overall Amount Of Bone Loss (mean Of The Two Surfaces); The Recorded Mean And Standard Deviation Values Of Amounts Of Bone Loss Were 0.50 ? 0.09 Mm And 0.53 ? 0.07 Mm For Immediate And Delayed Loading Groups, Respectively. There Was No Statistically Significant Difference Between The Two Groups (P-value = 0.545). Conclusions Immediate Loading For Posterior Mandibular Teeth Is A Viable Technique And Gives A Predictable Results

Sara Khaled Selim, Mai Mahmoud Yousry, Ahmed Abd El-Fattah Al-Zohairy And Mohamed Refaat El-Bialy ,

ABSTRACT
This Study Was Performed To Evaluate Microhardness And Fracture Resistance Of Sonic-fill Versus Bulk-fill Resin Composite Restorations. Materials And Methods A Total Number Of 80 Standardized MOD Cavities Were Prepared In 80 Maxillary Premolars. The Teeth Were Randomly Divided Into Two Equal Groups, Of 40 Teeth Each, According To The Material; Either SonicFill Resin Or X-tra Fil Resin Composite. Each Group Was Divided Into Two Equal Subgroups, Of 20 Teeth Each, According To Sonic Vibration Applied; Either Application Of Resin Composite Using Sonic Vibration Or Without Sonic Vibration. Each Subgroup Was Divided Into 2 Classes, Of 10 Teeth Each, According To The Aging Duration; Either After 24 Hours Or 12 Months In Artificial Saliva At 37?C. Five Teeth From Each Class Were Used For Microhardness Testing And The Other Five Were Assigned For Fracture Resistance Testing. An Extra Group Of Five Unprepared Teeth Was Used As Sound Control For Fracture Resistance Test. Vickers Microhardness Test Was Performed With Load Of 300 Gm For 10 Seconds, Then HV Hardness Scale Was Used At 3 Depths. For Fracture Resistance, Teeth Were Subjected To Compressive Axial Loading Until Fracture Occurred.

Results: Regarding Microhardness, The Results Showed That X-tra Fil Had A Higher Mean Microhardness Number Than Sonicfill, Also It Showed That Aging Increased The Mean Microhardness On All Specimens. On The Other Hand, Vibration Had No Effect On Mean Microhardness. Moreover, Neither Of The Three Variables Implicated In This Study Had Any Significant Effect On The Fracture Resistance Within The Restored Groups. Nevertheless, Sonicfill Showed No Significant Difference When Compared With Control Group When Applied Without Vibration.

Conclusions: Regarding The Materials, X-tra Fil Showed Higher Microhardness Value Than SonicFill. On The Contrary, SonicFill Was Advantageous Over X-tra Fil Regarding Fracture Resistance, When Applied Without Vibration. However, With Vibration, Both Materials Behaved Similarly. Sonic Vibration Did Not Influence The Microhardness Nor The Fracture Resistance Of Both Materials.

Nada Mohamed Sherif , Hala Kamal Abdel Gaber And Ahmed Elsayed Hamed Amr,

ABSTRACT


Aim: 1ry Objective: To Compare Two Different Approaches Applied In Conjunction With Immediately Placed Dental Implant Regarding The Enhancement Of The Soft Tissue Profile Around The Implant. 1st Approach Is The Placement Of The Particulate Bone Graft In A Surgically Created Sub-periosteal Pouch Adjoining The Buccal Plate Around The Implant, While The 2nd Approach Is The Placement Of Connective Tissue Graft In Surgically Created Sub-periosteal Pouch Adjoining The Buccal Plate Around The Implant. 2ry Objective: To Compare The Formerly Described Approaches Regarding The Effect On The Labial Alveolar Bone Around The Immediate Dental Implant. Subjects And Methods: Sixteen Extraction Sockets In 16 Patients Were Included In This Study. Eight Of Them (test Group), Were Treated With Placing A Bone Graft Overlying The Buccal Bone Plate In A Surgically Created Pouch, And Eight Of Them (control Group) Were Treated With Placing A Subepithelial Connective Tissue Graft Overlying The Buccal Plate In A Surgically Created Pouch. Result: 1- Keratinized Gingival Thickness, In Group (1), The Mean Value Increased From Baseline To 9 Months. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.048). In Group (2), The Mean Value Increased From Baseline To 9 Months. Paired T Test Revealed That The Difference Was Extremely Statistically Significant (p=0.00). Regarding The Percent Of Change In Group (1) In Comparison To A Percent Of Change In Group (2), Mann Whitney U Test Revealed That The Difference Was Not Statistically Significant (p=0.44). 2- Keratinized Gingiva Width, In Group (1), The Mean Value Increased At 9 Months In Comparison To Baseline. Paired T Test Revealed That The Difference Was Not Statistically Significant (p=0.064). In Group (2), The Mean Value Decreased At 9 Months In Comparison To Baseline. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.02). 3- CBCT (measuring The Bucco-lingual Ridge Width): In Group (1), The Mean Value Decreased After Treatment. Paired T Test Revealed That The Difference Was Not Statistically Significant (p=0.268). In Group (2), The Mean Value Increased After Treatment. Paired T Test Revealed That The Difference Was Statistically Significant (p=0.013). And Regarding The Percent Of Change After Treatment, A Decrease Was Noted In Group (1), While An Increase Was Noted In Group (2). Mann Whitney U Test, Revealed That The Difference Was Statistically Significant (p=0.02). 4- Marginal Bone Level: Regarding The Percent Of Change Between Two Groups From Base-line To 9 Months, A Mean Percent Of Change Increase Was Recorded In Group (1), While A Mean Percent Of Change Decrease Was Noted In Group (2). Mann Whitney U Test, Revealed That The Difference Was Statistically Significant (p=0.01). Conclusion: Particulate Xenograft Used In Labial Sub-periosteal Pouch Around Immediate Implant Enhances The Gingival Biotype And Keratinized Gingival Width Thus Can Optimize The Soft Tissue Profile And Final Esthetics. Moreover, It Helps In Minimizing Crestal Bone Loss But Has No Remarkable Effect On Ridge Bucco-lingual Bone Changes.

Aisha Khaled, Nader El Bokle And Mohamed Ashraf,

ABSTRACT
Objective: The Aim Of This Study Was To Assess The Stability Of Immediate Two Piece Zirconium Implant Placed In Fresh Extraction Sockets In The Esthetic Zone Augmented By Autogenous Bone. Patients And Methods: 6 Immediate Implants Were Placed In Fresh Sockets In Esthetic Zones (anterior Maxillary Region) Using Hexalobe (two Pieces) Axis Biodental Implants****. Patients Were Examined Clinically And A CBCT Was Done For Each Patient Preoperatively Evaluating Bone Density. Atraumatic Extraction Was Done For Anterior Remaining Roots And Drilling Was Performed According To The Manufacturer Instructions Under Copious Irrigation Till Fixture Placement Then The Primary Implant Stability Was Measured Using The Resonance Frequency Analysis Via The Osstell ISQ System*****. Autogenous Bone Was Harvested From Symphysis Area To Fill The Gap Between The Implant And Socket Walls And A Collagen Membrane Was Placed. CBCT And Surgical Exposure Of The Implant Was Done After 4 Months Where Secondary Implant Stability Was Also Measured Using Osstell ISQ System. A Healing Abutment Was Placed For 2 Weeks Then Final Coronal Restoration Was Obtained.

Results:Healing Of Implants Was Uneventful. All Immediate Zirconium Implants Placed Were Stable With A Mean Primary Stabilityof 62.08 (? 1.71)and Mean Secondary Stability Of 67.08 (?1.30). There Was Non Significant Difference Between Preoperative And Postoperative Bone Density. Conclusion:Zirconium Implants Were Found To Be A Good Candidate In Esthetic Zones Overcoming Aesthetic Complications Arising From The Titanium Implants.

Aisha Abubaker Ali Shanan, Mohammed Hossam Eldin El Mallahi And Shaimaa Eliwa Ghazy,

ABSTRACT
Oral Cancer Is A Very Aggressive Malignant Tumor Which Is Considered The Sixth Most Common Malignancy Worldwide. Chemotherapy Still The Main Treatment For Malignancy To Improve The Survival Rate And Quality Of Life For Patients. 5-fluorouracil Considered As A Standard Chemotherapy Regimen In Cases Of Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma. However, The Resistance Of Malignant Cells To Chemotherapy Remains A Major Obstacle In Cancer Treatment. Recently, Exploring Natural Products With Anticancer Properties Become A Very Growing Area Of Study To Open The Gate For New Treatment Modalities. Eucalyptus Oil Consists Of Many Chemicals That Have Anticancer Effect, Especially Alpha-pinene And Beta-pinene. Many Other Chemicals Present In Eucalyptus Oil Are Still Under Study. Aims And
Objectives: The Objective Of The Present Study Was To Evaluate The Possible Cytotoxic Effect Of Eucalyptus Oil And 5-fluorouracil On Head And Neck Squamous Cell Carcinoma Cell Line And To Compare The Effect Of Eucalyptus Oil And 5-fluorouracil On The Expression Of The Apoptotic Marker (Caspase-3) In Head And Neck Squamous Cell Carcinoma Cell Line. Methods:Human Tongue Squamous Carcinoma Cell Line (SCC-15) Was Used In This Study.Different Concentrations Of 5-fluorouracil And Eucalyptus Oil Were Prepared And Applied For 24 And 48 Hours On The Used Cell Line. The Yellow Tetrazoliumsalt (MTT) Assay Was Used For Evaluation Of Cytotoxicity Ofeach5-fluorouracil And Eucalyptus Oil.The Quantitative Sandwich Immunoassay ELISA Technique Was Used For The Assessment Of Caspase-3 Expression In The Treated Cell Line.

Results: MTT Assay Revealed That 5-fluorouracil And Eucalyptus Oil Showed A Significant Cytotoxic Effecton SCC-15cell Line. The ELISA Assessment Of Caspase-3 Expression Revealed That There Was A Statistical Increase In Caspase-3 Expression In SCC-15cell Line Treated With5-fluorouracil Than Eucalyptus Oil. Conclusion: Both 5-FU And Eucalyptus Oil Are Cytotoxic To OSCC But 5-FU Is More Effective In Activation Of Apoptotic Pathways.

Moatz Aly Ahmed, Emad. M. Agamy, Ahmed. F. Shawky And Amr. I. Badr ,

ABSTRACT
Since Their Introduction, Implant-retained Overdentures Have Represented A Feasible, Economical, And Highly Successful Treatment Option For Completely Edentulous Patients. Different Attachment Systems Have Been Effectively Used To Retain These Implant Overdentures, And Each System Has Advantages And Disadvantages. The Purpose Of This Study Was To Compare The Retentive Capabilities Of The Retention Sil Material And The Conventional Attachment Housing Of Locator Or Ball And Socket In Two Implant Retained Mandibular Overdenture And The Effect Of 3 Years Of Simulated Insertion And Removal.

Materials and Methods: An Acrylic Model Resembling Edentulous Mandible And Overdenture Were Constructed. Two Parallel Implant Analogues Were Inserted In The Canine Region. Two Attachment Systems Were Used With Their Prefabricated Matrices (Dentium Locator Clear And Dentium Ball Clear) Were Used; The Prefabricated Nylon Caps Were Replaced With Retention Sil Material. All Samples Were Subjected To 3240 Cycles Of Insertion And Removal To Simulate 3 Years Of Clinical Usage. The Universal Testing Machine Was Used To Record The Retentive Capabilities Of Different Attachment Systems.

Results: One-way ANOVA Followed By Tukey Post Hoc Test Was Used To Compare Between More Than Two Groups In Non-related Samples. There Was A Significant Difference In The Retention Capacity (p ?0.05) That Showed Higher Retention For Prefabricated Attachment Cap Materials Over The Retention Sil Material Where The Locator Attachment Showed The Highest Retention Value Either With Prefabricated Caps Or With Retention Sil Material.

Conclusions: From The Result Of This Study, It Can Be Concluded That: The Retentive Forces Of Implant Overdenture Stud Attachments Are Different And Should Be Considered During Attachment Selection. Prefabricated Attachment Matrices Give Higher Retentive Force Than Custom Made Matrices.

Mohamed Nabil Hassan, Nadia Ahmed Abbas And Mohamed Faroukabdallah,

ABSTRACT
Purpose:The Aim Of This In-vitro Study Was To Compareto The Retention Of Esthetic Saddle Lock Clasp Versus Conventional (Aker) Clasps In Bilateral Bounded Removable Partial Denture Cases.

Materials and Methods: Two Standard Experimental Models Of Maxillary Edentulous Case (Kennedy Class III With Modification I) Missing Right And Left Second Premolar And First Molar Were Fabricated To Be Used As A Master Model To Simulate The Oral Cavity. Eleven Cobalt-chromiums (Co-Cr) Alloy Frameworks Of Each Clasp Design Were Engaged 0.01 Inch Undercut For All Clasps, Mesiobuccal Of First Premolar And Distobuccal Of Second Molar On Both Sides For Aker And On Disto-proximal At The Axial Of The Buccal Premolar And On Mesio-proximal At The Axial Of The Buccal Molar On Both Sides Of Equipoise Clasp. The Loop Was Centralized Andsoldered Into The Major Connector.Digital Force Gauge Was Used For Both Groups To Measure The Retention. The Pulling Force Was Gradually Applied Until The Framework Was Dislodged.

Results: The Highest Mean Value Of Retention Was Found In (Aker Clasp) (94.85 ? 7.17) While, The Lowest Mean Value Of Retention Was Found In (saddle Lock Clasp) (61.06 ? 3.52). Conclusion: It Could Be Concluded That The Mean Retentive Force Required To Remove The Saddle Lock Clasp Was Found To Be Lower Than The Force Required Removing Aker Clasps.