Maram H. Abdelwahab, Nihal E. Sabet And Mohammed M. Nagy,

ABSTRACT


Aim: The Aim Of The Current Study Was To Assess The Concept Of Single File (Wave One-Wave One Gold) Versus Multiple Files (Protaper Universal Retreatment System) In Retreatment Procedure Regards Remaining Filling Material.

Materials and Methods: Forty-five Extracted Human Mandibular Molars With Completely Formed Apices And Root Curvature Ranging From 20-45 Degrees Were Selected From Outpatient Misr International University Clinic Of Surgery Department. Samples With Intact No Visible Cracks Or Fractures Were Selected. Samples Were Digitally Radiographed And Examined For Any Calcifications Or Resorption In Roots. Teeth With Severe Curvature Or Root Caries Were Excluded. Soft Tissue And Calculus Deposits Were Removed Using Ultrasonic Scalers, Then Autoclaved And Stored In 0.2% Thymol. Occlusal Surface Was Flattened By Safe Sided Diamond Discs To Obtain 15mm Working Length. Mesiobuccal Canals Were Prepared With Protaper File System Up To Size F2 Using X Smart Plus Electric Motor According To Manufacture Instruction. At Each Instrument Change Irrigation Was Done With 10 ML Of 2.5% NaOCl Solution Delivered Using Syringe 27-gauge Needle, When Instrumentation Of Root Canal Is Finished, 17% Ethylenediaminetetraacetic Acid (EDTA) Was Used To Remove The Smear Layer And Finally Washed Using Distilled Water (5 ML) So As To Eradicate Solution Used. Final Dryness Was Performed Using Paper Points. All Samples Were Obturated By Gutta-percha Master Cone Size F2 Protaper Guttapercha And Auxillaries #25 And AH Plus Sealer Using Lateral Compaction Technique With Spreader Shorter Than Working Length By 2mm. Samples Were Sectioned Into Two Halves Mesial And Distal, Distal Roots Were Discarded And Mesiobuccal Canal Marked With Blue Marker For Cone Beam Computed Tomography Scanning.

Results: Area Fraction Results Showed That There Was A Statistically Significant Difference Between Groups In Which Wave One Gold Recorded The Highest Area Fraction Followed By Wave One Followed By Protaper Retreatment. Conclusion: The Rotation Motion Proved To Be More Efficient In Retreatment Procedure.

Mohmmed Harris, Magdy Mohammed And Reham Hassan,

ABSTRACT
The Aim Of The Study Was To Compare Between XP Finisher File, XP Finisher R File And Passive Ultrasonic Irrigation On The Removal Of Smear Layer After Root Canal Retreatment. A Total Of 75 Single Rooted Human Mandibular Premolars Were Decoronized, Instrumented Using I-Race Rotary Files And Filled With Warm Gutta-percha And Total Fill Bioceramic Sealer Using Vertical Condensation Technique. Retreatment Was Performed With D-Race Rotary Files With The Help Of Gutta-percha Solvent. Samples Were Divided Into Three Experimental Groups And Two Control Groups (positive And Negative) After The Removal Of Filling Material According To Irrigation Protocol; Group A(positive Control), Group B(negative Control), Group C(XP Finisher), Group D(XP Finisher R), Group E(Passive Ultrasonic Irrigation) . Samples Were Sectioned Longitudinally And Prepared For Scanning Electron Microscope (SEM) To Evaluate Smear Layer Removal. The Percentages Of Cleaned Canal Walls In Each Third Of The Canal Were Determined Using Image J Software. Data Were Collected And Statistically Analyzed. Results Showed That None Of The Experimental Irrigation Techniques Used Resulted In Complete Canal Cleanliness. However Xp Finisher R File And Xp Finisher Fileshowed Better Cleaning Ability To Remove Smear Layer Compared To Passive Ultrasonic Irrigation In All Thirds Of Each Root Canal.

Radwa A. Dardeer And Mervat I. Fawzy,

ABSTRACT
Purpose Assessment Of The Surface Roughness Of Root Canal And Its Correlation With Bioceramic Sealer Bond Strength Following Final Irrigation By Chitosan. Material And Methods 50 Extracted Upper Centrals Were Selected And Prepared Using Universal ProTaper Rotary Files And 14 Ml 2.6% NaOCL Then The Samples Were Equally Distributed Into 2 Main Groups (20 Samples Each) Depending On The Type Of The Final Rinse. Group I: 0.2% Chitosan Acetate, Group II: 17 % Ethylenediamine Tetra Acetic Acid (EDTA), Control Group (10 Samples): Sterile Saline. Each Main Group Was Further Equally Distributed Into 2subgroups (10 Samples Each). Subgroup A: For Surface Roughness Evaluation. Subgroup B: For Push Out Bond Strength Evaluation. Surface Roughness Was Evaluated Using Digital Microscope. The Push Out Bond Strength Test Was Carried On Using Universal Testing Machine. The Sealer Penetration Inside The Dentinal Tubules Was Seen Under Scanning Electron Microscope (SEM) In Selected Samples. Results Regarding The Results Of Subgroup A, At All Levels, The Highest Value Of The Average Roughness Deviation (Ra) Was Recorded In Samples Treated With 17% EDTA, While The Lowest Value Was Recorded With The Saline Group And There Was No Statistical Significant Difference Among The Tested Groups. Regarding The Results Of Subgroup B, At All Levels, The Highest Median Push Out Bond Strength Was Recorded In Samples Treated With 17% EDTA, While The Lowest Value Was Recorded With The Saline Group And There Was No Statistical Significant Difference Among The Tested Groups Except At The Apical Levels Where The Difference Statistically Significant Among The Tested Groups. SEM Observation Of Sealer/ Dentin Interface Revealed Few Traces Of Sealer Penetration With Samples Treated With 17% EDTA And 0.2% Chitosan Acetate. Conclusion EDTA 17% As A Final Rinse Produced Higher Value Of Surface Roughness Compared To 0.2% Chitosan Acetate. The Push Out Bond Strength Results Of 0.2% Chitosan Acetate Was Comparable To That Of 17%EDTA When Applicated As A Final Rinse. There Is A Linear Relation Between Ra And The Push Out Bond Strength Of Bioceramic Sealer In Groups I, II.

Amr Ayman Abo El Enin Ahmed Randa Al Boghdady And Geraldine Ahmed,

ABSTRACT


Introduction: Many Endodontic Instrumentation Techniques Have Been Innovated. However, All Of Them Were Associated With Some Degree Of Debris Extrusion, An Important Cause Of Post-endodontic Pain. This Study Was Designed To Compare The Influence Of Two Different Kinematics Of Rotary Nickel-titanium Instrumentation Systems: Full Rotation Files (ProTaper Next) Versus Reciprocation Files (Reciproc) On The Incidence Of Postoperative Pain After Multiple Visit Endodontic Treatment In Asymptomatic Necrotic Mandibular Molars.

Materials and Methods: Sixty Patients With Asymptomatic Necrotic Mandibular Molars Were Included. After Confirming The Diagnosis Clinically And Radiographically, Patients Were Randomly Assigned Into Two Equal Groups Of 30 Patients Each. Standard Endodontic Treatment Was Performed In Two Visits. The Patients In The Intervention Group Were Treated Using Reciproc Reciprocating Files During Cleaning And Shaping; While ProTaper Next Rotary Files Were Used During Cleaning And Shaping Of Root Canals In Patients Assigned To The Comparator Group. 2.5% Sodium Hypochlorite Was Used For Irrigation And Obturation Was Performed A Week Later Using The Modified Single Cone Technique With A Resin Sealer. Pain Was Assessed Pre-operatively And The Tooth Was Confirmed To Be Asymptomatic, Then After 6, 12, 24 And 48 Hours After Root Canals Instrumentation, And After 6- And 12-hours Following Root Canal Obturation. Numeric Pain Rating Scale (NRS) Was Used As The Primary Outcome Measure. Patients Were Given A Placebo To Be Administered In Case Of Mild Pain And An Analgesic Was Prescribed In Case Of Emergency. All Demographic Data And NRS Scores Were Collected From The Patients And Statistically Analyzed.

Results: Results Showed That, Reciproc Files Caused A Statistically Significant Increase In The Incidence Of Pain After 6- And 12-hours Following Root Canal Instrumentation (P Value= 0.046, 0.042 Respectively). Conclusion: Within The Limitation Of This Study It Was Concluded That Reciproc Files In Reciprocating Motion Increase The Incidence Of Post-operative Pain In The First 12 Hours After Cleaning And Shaping.

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Samah Sayed Mehanny , Zeinab Amin Salem And Mohamed Khaled Mohamed Maria,

ABSTRACT
Background: Hepatitis C Virus Is A Main Cause For Liver Disease All Over The World. For Treatment Of Hepatitis C Virus, FDA Approved A New Direct Antiviral Drug, A Nucleoside Analogue, Called Sofosbuvir (Trade Name Is Sovaldi). This Drug Is Capable Of Inhibiting Viral NS5B Protein. Sovaldi Has Manifested Many Side Effects Like Colitis, Oral Ulcers, Headache, Nausea & Vomiting, But The Most Common Side Effect Is Fatigue. Aim : This Study Aimed To Assess The Side Effects Of Sofosbuvir On Masseter Muscles In Albino Rats. It Was Evaluated Histologically And By Measuring Calcium Level.

Materials and Methods: Forty Two Rats Were Divided Into Three Groups, Fourteen Rats Each. Group I: A Control Group, Kept On Normal Diet. Group II And III : Sovaldi Was Administered 40 Mg/kg/day For 30 Days And 60 Days Respectively. At The End Of The Experiment, Rats Were Sacrificed, Masseter Muscles Were Stained With Hematoxylin And Eosin Stain And Calcium Level Was Checked.

Results: Sovaldi Administration For 30 Days Caused Muscle Fiber Clumping, Hyaline Degeneration And Elevation In Intracellular Calcium Level In Masseter Muscles. However, Prolonged Sovaldi Administration (for 60 Days) Caused Adaptive Response Of The Tissue To The Drug.

Conclusions: Sovaldi Administration Caused Structural Changes In Masseter Muscle Fibers That Could Be The Cause Of Fatigue Associated With Sovaldi Treatment Based Regimens

Abdalla Ashraf Nadiem, Amr Helmy El Bolok And Sherif Farouk El-Gayar ,

ABSTRACT
Background: The World Health Organization (WHO) Reported Oral Cancer As Having One Of The Highest Mortality Ratios Amongst All Malignancies. Sinapic Acid Is One Of The Phenolic Compounds Which Considered A Group Of Key Plant Metabolites Which Can Induce Apoptosis In Laryngeal Carcinoma Cells. Aim Of This Study: The Aim Of The Study Is To Investigate The Influence Of Sinapic Acid Versus Nano Sinapic Acid On Induction Of Apoptosis In Human Laryngeal Carcinoma Cell Line Using PCR.

Materials & Methods: Treatment Of Cell Line (HEp-2) By Different Concentrations Of Sinapic Acid And Nano-sinapic Acid Was Done To Assess The Viability Of The Treated Cells To Determine The Percentages Of Viable Cells That Was Monitored Using MTT Assay And To Asses Ahe Apoptotic Effect Of These Drugs Using Real Time PCR.

Results: The Mean Viability Percentage Of Sinapic Acid And Nano-sinapic Acid Treated Cells (in Relation To Control Cells) Increased As Sinapic And Nano-sinapic Acid Concentration Decreased From 1000 MM To 4.88mM In Which The IC50 Of Sinapic Acid Is 565.42 MM.and 644.15 For Nano-sinapic Acid. There Is Increase In Fold Change In Apoptotic Genes (caspase And P53) Which Indicate The Apoptotic Activity Of Sinapic And Nano-sinapic Acid. It Was Concluded That Sinapic Acid Induce Apoptosis And Change Cancer Cell Morphology Due To Their Pro-apoptotic Activity.

Islam Refaat Ali Ahmed And Manal Rafei Hassan ,

ABSTRACT

Objectives: The Aim Of The Study Is To Assess The Microleakage Of Laminate Veneer Constructed Of Two Ceramic Materials.

Materials and Methods: Forty Recently Extracted Caries Free Human Upper Central Incisors Were Collected, Cleaned Then Disinfected. The Teeth Were Divided Randomly Regarding The Material (Hybrid Ceramic And High Translucent Zirconia) Into 2 Groups N=20. The Teeth Were Prepared In A Feather Edge Design Then Their Laminate Veneers Were Designed And Milled By CAD CAM System. The Porcelain Laminate Veneers Were Cemented To The Prepared Teeth, Thermocycled, Stored In Fuchsine Dye For 24 H And Then Sectioned Labiopalatally. The Samples Were Investigated Incisally And Cervically For Dye Penetration By The Stereomicroscope. The Obtained Data Were Then Statistically Analyzed Using The 2 Way Anova And Independent Student T Test.

Results: Using The Independent Samples T Test, It Was Found That There Was Significant Microleakage Difference Between The Two Material Types. Vita Enamic Showed Low Microleakage Than Zirconia In Both Incisal And Cervical Margins. Conclusion: There Was Significant Relation Between The Microleakage And The Material Type. Vita Enamic Has Better Marginal Sealing Than Zirconia.

Hadeer Abd Elhady Abd Elhameed, Nadia Ahmed Abbas And Nagla M.H Nassouhy,

ABSTRACT
Randomized Clinical Trial Was Carried Out To Compare Between Biting Force Of Mandibular Complete Denture Constructed From Two Different Materials; Metal Reinforced Polyamide And Conventional PMMA. Twenty Four Completely Edentulous Patients. The Patients Were Divided Into Two Equal Groups, Group I Received Conventional Maxillary And Mandibular Heat Cured PPMA And Group II Received Conventional Heat Cured Maxillary Denture And Metal Reinforced Polyamide Mandibular Denture. Patients Of Both Groups Were Evaluated By Biting Force Measurements At The Time Of Prosthesis Insertion As Well As Three And Four Weeks Later By Load Star Sensor. The Results; There Was No Statistical Significant Difference In Biting Force Between Conventional Heat Cured PMMA And Metal Reinforced Polyamide Mandibular Denture During All Follow Up Periods.

Youssef Y. Ashour, Samir I. Bakry , Sanaa H. Abd Elkadr And Fayzal Elabbasy,

ABSTRACT
BACKGROUND: Veneered All-ceramic Restorations Are Associated With A High Incidence Of Chipping And Veneer Delamination From The Inner Core. Monolithic All-ceramic Crowns Facilitate The Fabrication Process And Minimize Residual Stresses Between Core And Veneer. A New Material, Zirconia-reinforced Lithium Silicate (ZRL), Celtra Duo Was Recently Introduced For Fabrication Of Monolithic Anterior Crowns To Overcome The Aesthetic Drawbacks Of Traditional Zirconia And Also To Improve The Strength Of The Lithium Disilicate. Aim Of The Study: To Evaluate The Biaxial?flexural?strength Of CAD/CAM: Zirconia Reinforced Lithium Di Silicat And To Compare It With Lithium Silicate Glass-ceramic Crowns.

Materials and Methods: Thirty Monolithic Ceramic Specimens Will Be Fabricated And Divided Into THREE Main Groups; Group I: CAD/CAM ZLS Celtra Duo Milled And Polished, Group II CAD /CAM ZLS Celtra Duo Milled And Glazed & Group III: CAD/CAM Lithium Silicate Glass-ceramic (e.max CAD). For Evaluation Of The Biaxial?flexural?strength 30 Ceramic Disc Specimens (10mm Diameter ? 1.5mm Thickness) Ten Specimens From Each Material(N=10), Subgroups Ia, IIa, IIIa Will Be Fabricated According To The Manufacturers? Instructions And Thermocycled To Simulate One Year Clinical Service. Biaxial Flexural Strength Will Be Measured For The Same Specimens (Ia, IIa, IIIa). For Evolution Of Marginal Fit 30 Ceramic Crowns Will Be Fabricated, Ten Crowns From Each Material (N=10), Subgroups Ia, IIa, IIIa.